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Comprehensive imaging of residual/ recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT.

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Title: Comprehensive imaging of residual/ recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT.
Authors: Ng SH (AUTHOR), Chan SC (AUTHOR), Yen TC (AUTHOR), Liao CT (AUTHOR), Chang JT (AUTHOR), Ko SF (AUTHOR), Wang HM (AUTHOR), Lin CY (AUTHOR), Chang KP (AUTHOR), Lin YC (AUTHOR), Ng, Shu-Hang1 (AUTHOR), Chan, Sheng-Chieh (AUTHOR), Yen, Tzu-Chen (AUTHOR), Liao, Chun-Ta (AUTHOR), Chang, Joseph Tung-Chieh (AUTHOR), Ko, Sheung-Fat (AUTHOR), Wang, Hung-Ming (AUTHOR), Lin, Chin-Yu (AUTHOR), Chang, Kai-Ping (AUTHOR), Lin, Yu-Chun (AUTHOR)
Source: European Radiology. Sep2010, Vol. 20 Issue 9, p2229-2240. 12p.
Abstract: Objective: To prospectively compare the diagnostic potential of 3-T wholebody magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the detection of residual/recurrent nasopharyngeal carcinoma (NPC).Methods: We enrolled 179 NPC patients at high risk of residual disease or with suspected recurrence. WB-MRI and FDG-PET-CT were obtained with an interval of <10 days.Results: Fifty-five (30.7%) patients were found to have residual/recurrent tumours. In a patient-based analysis, the sensitivity, specificity and diagnostic capability of WB-MRI were similar to those of FDG-PET-CT (90.9% vs. 87.3%, P=0.69; 91.1% vs. 90.3%, P>0.99; 0.929 vs. 0.924, P=0.83, respectively). Combined interpretation of WB-MRI with FDGPET-CT increased the sensitivity to 94.5%. A slight improvement in the diagnostic capability was obtained using a combined interpretation of WB-MRI and FDG-PET-CT over WB-MRI alone (0.952 vs. 0.929, P=0.22) and FDG-PET-CT alone (0.952 vs. 0.924, P=0.11).Conclusions: Three-Tesla WB-MRI achieved a similar diagnostic capability to FDGPET-CT for the detection of residual/recurrent NPC. Both techniques have different advantages, and their combined interpretation can yield a slightly higher diagnostic capability. In clinical practice, 3-T WB-MRI can offer an accurate and comprehensive assessment of residual/recurrent NPC. [ABSTRACT FROM AUTHOR]
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Abstract:<bold>Objective: </bold>To prospectively compare the diagnostic potential of 3-T wholebody magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the detection of residual/recurrent nasopharyngeal carcinoma (NPC).<bold>Methods: </bold>We enrolled 179 NPC patients at high risk of residual disease or with suspected recurrence. WB-MRI and FDG-PET-CT were obtained with an interval of <10 days.<bold>Results: </bold>Fifty-five (30.7%) patients were found to have residual/recurrent tumours. In a patient-based analysis, the sensitivity, specificity and diagnostic capability of WB-MRI were similar to those of FDG-PET-CT (90.9% vs. 87.3%, P=0.69; 91.1% vs. 90.3%, P>0.99; 0.929 vs. 0.924, P=0.83, respectively). Combined interpretation of WB-MRI with FDGPET-CT increased the sensitivity to 94.5%. A slight improvement in the diagnostic capability was obtained using a combined interpretation of WB-MRI and FDG-PET-CT over WB-MRI alone (0.952 vs. 0.929, P=0.22) and FDG-PET-CT alone (0.952 vs. 0.924, P=0.11).<bold>Conclusions: </bold>Three-Tesla WB-MRI achieved a similar diagnostic capability to FDGPET-CT for the detection of residual/recurrent NPC. Both techniques have different advantages, and their combined interpretation can yield a slightly higher diagnostic capability. In clinical practice, 3-T WB-MRI can offer an accurate and comprehensive assessment of residual/recurrent NPC. [ABSTRACT FROM AUTHOR]
ISSN:09387994
DOI:10.1007/s00330-010-1784-9