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Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla--a pilot study.

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Title: Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla--a pilot study.
Authors: von Knobelsdorff-Brenkenhoff F (AUTHOR), Frauenrath T (AUTHOR), Prothmann M (AUTHOR), Dieringer MA (AUTHOR), Hezel F (AUTHOR), Renz W (AUTHOR), Kretschel K (AUTHOR), Niendorf T (AUTHOR), Schulz-Menger J (AUTHOR), von Knobelsdorff-Brenkenhoff, Florian1 (AUTHOR), Frauenrath, Tobias (AUTHOR), Prothmann, Marcel (AUTHOR), Dieringer, Matthias A (AUTHOR), Hezel, Fabian (AUTHOR), Renz, Wolfgang (AUTHOR), Kretschel, Kerstin (AUTHOR), Niendorf, Thoralf (AUTHOR), Schulz-Menger, Jeanette (AUTHOR)
Source: European Radiology. Dec2010, Vol. 20 Issue 12, p2844-2852. 9p.
Abstract: Objectives: Interest in cardiovascular magnetic resonance (CMR) at 7 T is motivated by the expected increase in spatial and temporal resolution, but the method is technically challenging. We examined the feasibility of cardiac chamber quantification at 7 T.Methods: A stack of short axes covering the left ventricle was obtained in nine healthy male volunteers. At 1.5 T, steady-state free precession (SSFP) and fast gradient echo (FGRE) cine imaging with 7 mm slice thickness (STH) were used. At 7 T, FGRE with 7 mm and 4 mm STH were applied. End-diastolic volume, end-systolic volume, ejection fraction and mass were calculated.Results: All 7 T examinations provided excellent blood/myocardium contrast for all slice directions. No significant difference was found regarding ejection fraction and cardiac volumes between SSFP at 1.5 T and FGRE at 7 T, while volumes obtained from FGRE at 1.5 T were underestimated. Cardiac mass derived from FGRE at 1.5 and 7 T was larger than obtained from SSFP at 1.5 T. Agreement of volumes and mass between SSFP at 1.5 T and FGRE improved for FGRE at 7 T when combined with an STH reduction to 4 mm.Conclusions: This pilot study demonstrates that cardiac chamber quantification at 7 T using FGRE is feasible and agrees closely with SSFP at 1.5 T. [ABSTRACT FROM AUTHOR]
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Abstract:<bold>Objectives: </bold>Interest in cardiovascular magnetic resonance (CMR) at 7 T is motivated by the expected increase in spatial and temporal resolution, but the method is technically challenging. We examined the feasibility of cardiac chamber quantification at 7 T.<bold>Methods: </bold>A stack of short axes covering the left ventricle was obtained in nine healthy male volunteers. At 1.5 T, steady-state free precession (SSFP) and fast gradient echo (FGRE) cine imaging with 7 mm slice thickness (STH) were used. At 7 T, FGRE with 7 mm and 4 mm STH were applied. End-diastolic volume, end-systolic volume, ejection fraction and mass were calculated.<bold>Results: </bold>All 7 T examinations provided excellent blood/myocardium contrast for all slice directions. No significant difference was found regarding ejection fraction and cardiac volumes between SSFP at 1.5 T and FGRE at 7 T, while volumes obtained from FGRE at 1.5 T were underestimated. Cardiac mass derived from FGRE at 1.5 and 7 T was larger than obtained from SSFP at 1.5 T. Agreement of volumes and mass between SSFP at 1.5 T and FGRE improved for FGRE at 7 T when combined with an STH reduction to 4 mm.<bold>Conclusions: </bold>This pilot study demonstrates that cardiac chamber quantification at 7 T using FGRE is feasible and agrees closely with SSFP at 1.5 T. [ABSTRACT FROM AUTHOR]
ISSN:09387994
DOI:10.1007/s00330-010-1888-2