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Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?

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Title: Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?
Authors: Friedrich KM (AUTHOR), Shepard T (AUTHOR), Chang G (AUTHOR), Wang L (AUTHOR), Babb JS (AUTHOR), Schweitzer M (AUTHOR), Regatte R (AUTHOR), Friedrich, Klaus M1 (AUTHOR), Shepard, Timothy (AUTHOR), Chang, Gregory (AUTHOR), Wang, Ligong (AUTHOR), Babb, James S (AUTHOR), Schweitzer, Mark (AUTHOR), Regatte, Ravinder (AUTHOR)
Source: European Radiology. Jun2010, Vol. 20 Issue 6, p1532-1538. 7p.
Abstract: Objective: To assess the relationship between T2 values of femorotibial cartilage and knee alignment in patients with clinical symptoms of medial osteoarthritis (OA).Methods: Twenty-four patients (mean age +/- standard deviation, 62.5 +/- 9.9 years) with clinical symptoms of medial knee OA, 12 with varus and 12 with valgus alignment of the femorotibial joint, were investigated on 3T MR using a 2D multi-echo spin echo (MESE) sequence for T2 mapping. Analysis of covariance, Spearman correlation coefficients, exact Mann-Whitney tests, and Fisher's exact tests were used for statistical analysis.Results: Overall the T2 values of cartilage in the medial compartment (median +/- interquartile-range, 49.44 +/- 6.58) were significantly higher (P = 0.0043) than those in the lateral compartment (47.15 +/- 6.87). Patients with varus alignment (50.83 +/- 6.30 ms) had significantly higher T2 values of cartilage (P < 0.0001) than patients with valgus alignment (46.20 +/- 6.00 ms). No statistically significant association between the T2 values of cartilage (in either location) and the Kellgren Lawrence score was found in the varus or in the valgus group.Conclusion: T2 measurements were increased in medial knee OA patients with varus alignment, adding support to the theory of an association of OA and joint alignment. [ABSTRACT FROM AUTHOR]
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Abstract:<bold>Objective: </bold>To assess the relationship between T2 values of femorotibial cartilage and knee alignment in patients with clinical symptoms of medial osteoarthritis (OA).<bold>Methods: </bold>Twenty-four patients (mean age +/- standard deviation, 62.5 +/- 9.9 years) with clinical symptoms of medial knee OA, 12 with varus and 12 with valgus alignment of the femorotibial joint, were investigated on 3T MR using a 2D multi-echo spin echo (MESE) sequence for T2 mapping. Analysis of covariance, Spearman correlation coefficients, exact Mann-Whitney tests, and Fisher's exact tests were used for statistical analysis.<bold>Results: </bold>Overall the T2 values of cartilage in the medial compartment (median +/- interquartile-range, 49.44 +/- 6.58) were significantly higher (P = 0.0043) than those in the lateral compartment (47.15 +/- 6.87). Patients with varus alignment (50.83 +/- 6.30 ms) had significantly higher T2 values of cartilage (P < 0.0001) than patients with valgus alignment (46.20 +/- 6.00 ms). No statistically significant association between the T2 values of cartilage (in either location) and the Kellgren Lawrence score was found in the varus or in the valgus group.<bold>Conclusion: </bold>T2 measurements were increased in medial knee OA patients with varus alignment, adding support to the theory of an association of OA and joint alignment. [ABSTRACT FROM AUTHOR]
ISSN:09387994
DOI:10.1007/s00330-009-1689-7