Prevalence and correlates of pulmonary emphysema in smokers and former smokers. A densitometric study of participants in the ITALUNG trial.
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| Title: | Prevalence and correlates of pulmonary emphysema in smokers and former smokers. A densitometric study of participants in the ITALUNG trial. |
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| Authors: | Camiciottoli G (AUTHOR), Cavigli E (AUTHOR), Grassi L (AUTHOR), Diciotti S (AUTHOR), Orlandi I (AUTHOR), Zappa M (AUTHOR), Picozzi G (AUTHOR), Pegna AL (AUTHOR), Paci E (AUTHOR), Falaschi F (AUTHOR), Mascalchi M (AUTHOR), Camiciottoli, Gianna1 (AUTHOR), Cavigli, Edoardo (AUTHOR), Grassi, Luca (AUTHOR), Diciotti, Stefano (AUTHOR), Orlandi, Ilaria (AUTHOR), Zappa, Marco (AUTHOR), Picozzi, Giulia (AUTHOR), Pegna, Andrea Lopes (AUTHOR), Paci, Eugenio (AUTHOR) |
| Source: | European Radiology. Jan2009, Vol. 19 Issue 1, p58-66. 9p. |
| Abstract: | We assessed with computed tomography (CT) densitometry the prevalence of emphysema in 266 (175 men and 91 women; mean age 64 +/- 4 years) smokers and former smokers enrolled in the ITALUNG trial of lung cancer screening with low-dose thin-slice CT. Whole-lung volume and the relative area at -950 Hounsfield units (RA(950)) and mean lung attenuation (MLA) in 1 of every 10 slices (mean, 24 slices per subject) were measured. Lung volume, MLA and RA950 significantly correlated each other and with age. Average RA950 >6.8% qualifying for emphysema was present in 71 (26.6%) of 266 subjects, with a higher prevalence in men than in women (30.3% vs 19.8%; p = 0.003). Only in smokers was a weak (r = 0.18; p = 0.05) correlation between RA950 and packs/year observed. In multiple regression analysis, the variability of RA950 (R2 = 0.24) or MLA (R2 = 0.34) was significantly, but weakly explained by age, lung volume and packs/year. Other factors besides smoking may also have a significant role in the etiopathogenesis of pulmonary emphysema. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | We assessed with computed tomography (CT) densitometry the prevalence of emphysema in 266 (175 men and 91 women; mean age 64 +/- 4 years) smokers and former smokers enrolled in the ITALUNG trial of lung cancer screening with low-dose thin-slice CT. Whole-lung volume and the relative area at -950 Hounsfield units (RA(950)) and mean lung attenuation (MLA) in 1 of every 10 slices (mean, 24 slices per subject) were measured. Lung volume, MLA and RA950 significantly correlated each other and with age. Average RA950 >6.8% qualifying for emphysema was present in 71 (26.6%) of 266 subjects, with a higher prevalence in men than in women (30.3% vs 19.8%; p = 0.003). Only in smokers was a weak (r = 0.18; p = 0.05) correlation between RA950 and packs/year observed. In multiple regression analysis, the variability of RA950 (R2 = 0.24) or MLA (R2 = 0.34) was significantly, but weakly explained by age, lung volume and packs/year. Other factors besides smoking may also have a significant role in the etiopathogenesis of pulmonary emphysema. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09387994 |
| DOI: | 10.1007/s00330-008-1131-6 |
