Bibliographic Details
| Title: |
Low Temperature Syntheses and Reactivity of Cu2O2Active-Site Models. |
| Authors: |
Cooper Citek1, Sonja Herres-Pawlis1, T. Daniel P. Stack1 |
| Source: |
Accounts of Chemical Research. Aug2015, Vol. 48 Issue 8, p2424-2433. 10p. |
| Subjects: |
Reactivity (Chemistry), Oxidation, Enzymes, Biosynthesis, Low temperatures, Copper oxide, Oxidants & Antioxidants: Ultrastructure & Molecular Biology Protocols (Book) |
| Abstract: |
Nature’sfacility with dioxygen outmatches modern chemistryin the oxidation and oxygenation of materials and substrates for biosynthesisand cellular metabolism. The Earth’s most abundant naturallyoccurring oxidant isfranklypoorly understood and controlled,and thus underused. Copper-based enzyme metallocofactors are ubiquitousto the efficient consumption of dioxygen by all domains of life. Overthe last several decades, we have joined many research groups in thestudy of copper- and dioxygen-dependent enzymes through close investigationof synthetically derived, small-molecule active-site analogs. Simplecopper-dioxygen clusters bearing structural and spectroscopic similarityto dioxygen-activating enzymes can be probed for their fundamentalgeometrical, electronic, and reactive properties using the tools availableto inorganic and synthetic chemistry. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
