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A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.

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Bibliographic Details
Title: A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
Authors: Pin-Fang Lin1 pinfang.lin@bms.com, Blair, Wade1, Tao Wang2, Spicer, Timothy1, Qi Guo1, Nannan Zhou1, Yi-Fei Gong1, Wang, H.-G. Heidi1, Rose, Ronald1, Yamanaka, Gregory1, Robinson, Brett1, Chang-Ben Li1, Fridell, Robert1, Deminie, Carol1, Demers, Gwendeline1, Zheng Yang3, Zadjura, Liza3, Meanwell, Nicholas2, Colonno, Richard1
Source: Proceedings of the National Academy of Sciences of the United States of America. 9/16/2003, Vol. 100 Issue 19, p11013-11018. 6p. 1 Diagram, 5 Charts, 5 Graphs.
Subjects: Chemical inhibitors, HIV, Medical microbiology
Abstract: Describes a small molecule HIV-1 inhibitor that targets HIV-1 envelope and inhibits CD4 receptor binding. Design of cytotoxicity and time-of-addition study and pharmacokinetic research on animals; Inhibition of viral entry; Pharmacokinetic and safety profiles.
Database: Engineering Source
Description
Abstract:Describes a small molecule HIV-1 inhibitor that targets HIV-1 envelope and inhibits CD4 receptor binding. Design of cytotoxicity and time-of-addition study and pharmacokinetic research on animals; Inhibition of viral entry; Pharmacokinetic and safety profiles.
ISSN:00278424
DOI:10.1073/pnas.1832214100