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A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.

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Title: A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
Authors: Pin-Fang Lin1 pinfang.lin@bms.com, Blair, Wade1, Tao Wang2, Spicer, Timothy1, Qi Guo1, Nannan Zhou1, Yi-Fei Gong1, Wang, H.-G. Heidi1, Rose, Ronald1, Yamanaka, Gregory1, Robinson, Brett1, Chang-Ben Li1, Fridell, Robert1, Deminie, Carol1, Demers, Gwendeline1, Zheng Yang3, Zadjura, Liza3, Meanwell, Nicholas2, Colonno, Richard1
Source: Proceedings of the National Academy of Sciences of the United States of America. 9/16/2003, Vol. 100 Issue 19, p11013-11018. 6p. 1 Diagram, 5 Charts, 5 Graphs.
Subjects: Chemical inhibitors, HIV, Medical microbiology
Abstract: Describes a small molecule HIV-1 inhibitor that targets HIV-1 envelope and inhibits CD4 receptor binding. Design of cytotoxicity and time-of-addition study and pharmacokinetic research on animals; Inhibition of viral entry; Pharmacokinetic and safety profiles.
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 11051676
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.
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  Data: <searchLink fieldCode="AR" term="%22Pin-Fang+Lin%22">Pin-Fang Lin</searchLink><relatesTo>1</relatesTo><i> pinfang.lin@bms.com</i><br /><searchLink fieldCode="AR" term="%22Blair%2C+Wade%22">Blair, Wade</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tao+Wang%22">Tao Wang</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Spicer%2C+Timothy%22">Spicer, Timothy</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Qi+Guo%22">Qi Guo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Nannan+Zhou%22">Nannan Zhou</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yi-Fei+Gong%22">Yi-Fei Gong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wang%2C+H%2E-G%2E+Heidi%22">Wang, H.-G. Heidi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rose%2C+Ronald%22">Rose, Ronald</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yamanaka%2C+Gregory%22">Yamanaka, Gregory</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Robinson%2C+Brett%22">Robinson, Brett</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chang-Ben+Li%22">Chang-Ben Li</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fridell%2C+Robert%22">Fridell, Robert</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Deminie%2C+Carol%22">Deminie, Carol</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Demers%2C+Gwendeline%22">Demers, Gwendeline</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zheng+Yang%22">Zheng Yang</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zadjura%2C+Liza%22">Zadjura, Liza</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Meanwell%2C+Nicholas%22">Meanwell, Nicholas</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Colonno%2C+Richard%22">Colonno, Richard</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 9/16/2003, Vol. 100 Issue 19, p11013-11018. 6p. 1 Diagram, 5 Charts, 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Chemical+inhibitors%22">Chemical inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22HIV%22">HIV</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+microbiology%22">Medical microbiology</searchLink>
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  Label: Abstract
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  Data: Describes a small molecule HIV-1 inhibitor that targets HIV-1 envelope and inhibits CD4 receptor binding. Design of cytotoxicity and time-of-addition study and pharmacokinetic research on animals; Inhibition of viral entry; Pharmacokinetic and safety profiles.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=11051676
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        Text: English
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        Type: general
      – SubjectFull: HIV
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      – SubjectFull: Medical microbiology
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              Text: 9/16/2003
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              Y: 2003
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