All-Systolic Non-ECG-gated Myocardial Perfusion MRI: Feasibility of Multi-Slice Continuous First-Pass Imaging.
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| Title: | All-Systolic Non-ECG-gated Myocardial Perfusion MRI: Feasibility of Multi-Slice Continuous First-Pass Imaging. |
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| Authors: | Sharif, Behzad1,2, Arsanjani, Reza1,3,4, Dharmakumar, Rohan1,2,4, Bairey Merz, C. Noel2,3,4,5, Berman, Daniel S.1,3,4, Li, Debiao1,2,4 |
| Source: | Magnetic Resonance in Medicine. Dec2015, Vol. 74 Issue 6, p1661-1674. 14p. |
| Abstract: | Purpose: To develop and test the feasibility of a new method for non-ECG-gated first-pass perfusion (FPP) cardiac MR capable of imaging multiple short-axis slices at the same systolic cardiac phase. Methods: A magnetization-driven pulse sequence was developed for non-ECG-gated FPP imaging without saturationrecovery preparation using continuous slice-interleaved radial sampling. The image reconstruction method, dubbed TRACE, used self-gating based on reconstruction of a real-time imagebased navigator combined with reference-constrained compressed sensing. Data from ischemic animal studies (n=5) was used in a simulation framework to evaluate temporal fidelity. Healthy subjects (n=5) were studied using both the proposed approach and the conventional method to compare the myocardial contrast-to-noise ratio (CNR). Patients (n=2) underwent adenosine stress studies using the proposed method. Results: Temporal fidelity of the developed method was shown to be sufficient at high heart-rates. The healthy volunteers studies demonstrated normal perfusion and no dark-rim artifacts. Compared with the conventional scheme, myocardial CNR for the proposed method was slightly higher (8.660.6 versus 8.060.7). Patient studies showed stress-induced perfusion defects consistent with invasive angiography. Conclusion: The presented methods and results demonstrate feasibility of the proposed approach for high-resolution non-ECG-gated FPP imaging of 3 myocardial slices at the same systolic phase, and indicate its potential for achieving desirable image quality (high CNR and no dark-rim artifacts). [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Purpose: To develop and test the feasibility of a new method for non-ECG-gated first-pass perfusion (FPP) cardiac MR capable of imaging multiple short-axis slices at the same systolic cardiac phase. Methods: A magnetization-driven pulse sequence was developed for non-ECG-gated FPP imaging without saturationrecovery preparation using continuous slice-interleaved radial sampling. The image reconstruction method, dubbed TRACE, used self-gating based on reconstruction of a real-time imagebased navigator combined with reference-constrained compressed sensing. Data from ischemic animal studies (n=5) was used in a simulation framework to evaluate temporal fidelity. Healthy subjects (n=5) were studied using both the proposed approach and the conventional method to compare the myocardial contrast-to-noise ratio (CNR). Patients (n=2) underwent adenosine stress studies using the proposed method. Results: Temporal fidelity of the developed method was shown to be sufficient at high heart-rates. The healthy volunteers studies demonstrated normal perfusion and no dark-rim artifacts. Compared with the conventional scheme, myocardial CNR for the proposed method was slightly higher (8.660.6 versus 8.060.7). Patient studies showed stress-induced perfusion defects consistent with invasive angiography. Conclusion: The presented methods and results demonstrate feasibility of the proposed approach for high-resolution non-ECG-gated FPP imaging of 3 myocardial slices at the same systolic phase, and indicate its potential for achieving desirable image quality (high CNR and no dark-rim artifacts). [ABSTRACT FROM AUTHOR] |
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| ISSN: | 07403194 |
| DOI: | 10.1002/mrm.25752 |
