Bibliographic Details
| Title: |
A study on permeability transition pore opening and cytochrome c release from mitochondria, induced by caspase-3 in vitro. |
| Authors: |
Xia, Tian1,2, Jiang, Chunsun1,3, Li, Linjiang1, Wu, Caihong2, Chen, Quan1, Liu, Shu-sen1 |
| Source: |
FEBS Letters. Jan2002, Vol. 510 Issue 1-2, p62-66. 5p. |
| Subjects: |
Mitochondrial membranes, Mitochondrial enzymes, Permeability (Biology), Membrane potential, Gene amplification, Cytochrome c, Caspases |
| Abstract: |
We recently described that there is a feedback amplification of cytochrome c release from mitochondria by caspases. Here we investigated how caspases impact on mitochondria to induce cytochrome c release and found that recombinant caspase-3 induced opening of permeability transition pore and reduction of membrane potential in vitro. These events were inhibited by Bcl-xL, cyclosporin A and z-VAD.fmk. Moreover, caspase-3 stimulated the rate of mitochondrial state 4 respiration, superoxide production and NAD(P)H oxidation in a Bcl-xL- and cyclosporin A-inhibitable manner. These results suggest that caspase-3 induces cytochrome c release by inducing permeability transition pore opening which is associated with changes in mitochondrial respiration and redox potential. [ABSTRACT FROM AUTHOR] |
|
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Engineering Source |
