Bibliographic Details
| Title: |
Synthesis of 1,8-naphthyridines from 2-aminonicotinaldehydes and terminal alkynes. |
| Authors: |
Li, Binbin1, Nguyen, Steven1, Huang, Jianjun1, Wang, Gaigai1, Wei, Huiping1, Pereshivko, Olga P.1 olga@suda.edu.cn, Peshkov, Vsevolod A.1 vsevolod@suda.edu.cn |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2016, Vol. 57 Issue 18, p1958-1962. 5p. |
| Subjects: |
Chemical synthesis, Naphthyridines, Alkynes, Chemical reactions, Hydroamination |
| Abstract: |
A copper(II) triflate-catalyzed diethylamine-assisted protocol for the reaction of 2-aminonicotinaldehydes and terminal alkynes leading to 1,8-naphthyridines is described. The overall process presumably involves a copper(II) triflate-catalyzed hydroamination of the triple bond followed by the Friedländer-type condensation of the resulting enamine with 2-aminonicotinaldehyde. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
