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Modified glycogen as construction material for functional biomimetic microfibers.

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Title: Modified glycogen as construction material for functional biomimetic microfibers.
Authors: Rabyk, Mariia1 rabyk@imc.cas.cz, Hruby, Martin1 hruby@imc.cas.cz, Vetrik, Miroslav1 vetrix@seznam.cz, Kucka, Jan1 jkucka@centrum.cz, Proks, Vladimir1 proks@imc.cas.cz, Parizek, Martin2 parizek@biomed.cas.cz, Konefal, Rafal1 konefal@imc.cas.cz, Krist, Pavel3 krist@ujf.cas.cz, Chvatil, David3 chvatil@ujf.cas.cz, Bacakova, Lucie2 lucy@biomed.cas.cz, Slouf, Miroslav1 slouf@imc.cas.cz, Stepanek, Petr1 stepan@imc.cas.cz
Source: Carbohydrate Polymers. Nov2016, Vol. 152, p271-279. 9p.
Subjects: Glycogen, Construction materials, Biomimetic materials, Wound healing, Allylation
Abstract: We describe a conceptually new, microfibrous, biodegradable functional material prepared from a modified storage polysaccharide also present in humans (glycogen) showing strong potential as direct-contact dressing/interface material for wound healing. Double bonds were introduced into glycogen via allylation and were further exploited for crosslinking of the microfibers. Triple bonds were introduced by propargylation and served for further click functionalization of the microfibers with bioactive peptide. A simple solvent-free method allowing the preparation of thick layers was used to produce microfibers (diameter ca 2 μm) from allylated and/or propargylated glycogen. Crosslinking of the samples was performed by microtron beta-irradiation, and the irradiation dose was optimized to 2 kGy. The results from biological testing showed that these highly porous, hydrophilic, readily functionalizable materials were completely nontoxic to cells growing in their presence. The fibers were gradually degraded in the presence of cells. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:We describe a conceptually new, microfibrous, biodegradable functional material prepared from a modified storage polysaccharide also present in humans (glycogen) showing strong potential as direct-contact dressing/interface material for wound healing. Double bonds were introduced into glycogen via allylation and were further exploited for crosslinking of the microfibers. Triple bonds were introduced by propargylation and served for further click functionalization of the microfibers with bioactive peptide. A simple solvent-free method allowing the preparation of thick layers was used to produce microfibers (diameter ca 2 μm) from allylated and/or propargylated glycogen. Crosslinking of the samples was performed by microtron beta-irradiation, and the irradiation dose was optimized to 2 kGy. The results from biological testing showed that these highly porous, hydrophilic, readily functionalizable materials were completely nontoxic to cells growing in their presence. The fibers were gradually degraded in the presence of cells. [ABSTRACT FROM AUTHOR]
ISSN:01448617
DOI:10.1016/j.carbpol.2016.06.107