View in EDS

Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p' -DDE on the reproductive organs of the copepod Acartia tonsa.

Saved in:
Bibliographic Details
Title: Effects of anti-androgens cyproterone acetate, linuron, vinclozolin, and p,p' -DDE on the reproductive organs of the copepod Acartia tonsa.
Authors: Watermann, Burkard T.1, Albanis, Triantafyllos A.2, Galassi, Silvana3, Gnass, Katarina1, Kusk, Kresten O.4, Sakkas, Vasilios A.2, Wollenberger, Leah4
Source: Journal of Environmental Science & Health. Part A. Toxic/Hazardous Substances & Environmental Engineering. 2016, Vol. 51 Issue 13, p1111-1120. 10p.
Subjects: Cyproterone acetate, Acartia tonsa, Androgens, Vinclozolin, Genitalia physiology, Invertebrate reproduction, Spermatophores
Abstract: The study was performed to detect the effects of anti-androgenic compounds on the reproduction. In this paper alterations observed in the marine calanoid copepodAcartia tonsaexposed to environmental concentrations of cyproterone acetate (CPA), linuron (LIN), vinclozolin (VIN), and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) for 21 days covering a full life cycle are described. Histological alterations were studied with a focus on reproductive organs, gonad and accessory sexual glands. Exposure to ≥1.2 µg L−1CPA caused degeneration of spermatocytes and deformation of the spermatophore in males. In a single male exposed to 33 µg L−1CPA, an ovotestis was observed. In CPA exposed females, enhancement of oogenesis, increase in apoptosis and a decrease in proliferation occurred. Exposure of males to ≥12 µg L−1LIN caused degenerative effects in spermatogonia, spermatocytes and spermatids, and at 4.7 µg L−1LIN, the spermatophore wall displayed an irregular formation. In LIN exposed females, no such structural alterations were found; however, the proliferation index was reduced at 29 µg L−1LIN. At an exposure concentration of ≥100 µg L−1VIN, distinct areas in male gonad were stimulated, whereas others displayed a disturbed spermatogenesis and a deformed spermatophore wall. In VIN exposed femaleA. tonsa, no effects were observed. MaleA. tonsaexposed top,p'-DDE displayed an impairment of spermatogenesis in all stages with increased degrees of apoptosis. Inp,p'-DDE-exposed females, a statistical significant increase of the proliferation index and an intensification of oogenesis were observed at 0.0088 µg L−1. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Environmental Science & Health. Part A. Toxic/Hazardous Substances & Environmental Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:The study was performed to detect the effects of anti-androgenic compounds on the reproduction. In this paper alterations observed in the marine calanoid copepodAcartia tonsaexposed to environmental concentrations of cyproterone acetate (CPA), linuron (LIN), vinclozolin (VIN), and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) for 21 days covering a full life cycle are described. Histological alterations were studied with a focus on reproductive organs, gonad and accessory sexual glands. Exposure to ≥1.2 µg L−1CPA caused degeneration of spermatocytes and deformation of the spermatophore in males. In a single male exposed to 33 µg L−1CPA, an ovotestis was observed. In CPA exposed females, enhancement of oogenesis, increase in apoptosis and a decrease in proliferation occurred. Exposure of males to ≥12 µg L−1LIN caused degenerative effects in spermatogonia, spermatocytes and spermatids, and at 4.7 µg L−1LIN, the spermatophore wall displayed an irregular formation. In LIN exposed females, no such structural alterations were found; however, the proliferation index was reduced at 29 µg L−1LIN. At an exposure concentration of ≥100 µg L−1VIN, distinct areas in male gonad were stimulated, whereas others displayed a disturbed spermatogenesis and a deformed spermatophore wall. In VIN exposed femaleA. tonsa, no effects were observed. MaleA. tonsaexposed top,p'-DDE displayed an impairment of spermatogenesis in all stages with increased degrees of apoptosis. Inp,p'-DDE-exposed females, a statistical significant increase of the proliferation index and an intensification of oogenesis were observed at 0.0088 µg L−1. [ABSTRACT FROM AUTHOR]
ISSN:10934529
DOI:10.1080/10934529.2016.1199769