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Antimicrobial poly(ε-caprolactone)/thymol blends: Phase behavior, interactions and drug release kinetics.

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Title: Antimicrobial poly(ε-caprolactone)/thymol blends: Phase behavior, interactions and drug release kinetics.
Authors: Sanchez-Rexach, Eva1, Martínez de Arenaza, Inger1, Sarasua, Jose-Ramon1, Meaurio, Emilio1 emiliano.meaurio@ehu.es
Source: European Polymer Journal. Oct2016, Vol. 83, p288-299. 12p.
Subjects: Antimicrobial polymers, Caprolactones, Thymol, Pharmacokinetics, Miscibility, Ultraviolet spectroscopy
Abstract: Blends of poly(ε-caprolactone) (PCL) and thymol (THY) have been prepared by melt-mixing to obtain biodegradable materials with antibacterial properties. Miscibility and specific interactions have been investigated by means of DSC and FTIR, and the drug release kinetics of the PCL/THY blends have been analyzed using UV spectroscopy at 274 nm. The melting points of PCL and THY have been analyzed using melting point depression analysis, and the interaction energy density has been found to vary from B = −30 J/cm 3 in THY rich blends to B = 9 J/cm 3 in PCL rich blends. The former value indicates a thermodynamically miscible blend, but the latter is close to critical conditions, and the dependence of B on composition has been discussed. The study of the carbonyl and hydroxyl stretching regions of the FTIR spectra for different compositions of the blend reveals strong C O⋯H O hydrogen bonding interactions, supporting the miscibility of the PCL/THY blends. Finally, the analysis of the release kinetics of THY from the PCL/THY blends in phosphate buffered saline (PBS) solution at 37 °C (pH 7.4) shows that diffusion through the swelled polymeric chains is the leading mechanism for drug release. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Blends of poly(ε-caprolactone) (PCL) and thymol (THY) have been prepared by melt-mixing to obtain biodegradable materials with antibacterial properties. Miscibility and specific interactions have been investigated by means of DSC and FTIR, and the drug release kinetics of the PCL/THY blends have been analyzed using UV spectroscopy at 274 nm. The melting points of PCL and THY have been analyzed using melting point depression analysis, and the interaction energy density has been found to vary from B = −30 J/cm 3 in THY rich blends to B = 9 J/cm 3 in PCL rich blends. The former value indicates a thermodynamically miscible blend, but the latter is close to critical conditions, and the dependence of B on composition has been discussed. The study of the carbonyl and hydroxyl stretching regions of the FTIR spectra for different compositions of the blend reveals strong C O⋯H O hydrogen bonding interactions, supporting the miscibility of the PCL/THY blends. Finally, the analysis of the release kinetics of THY from the PCL/THY blends in phosphate buffered saline (PBS) solution at 37 °C (pH 7.4) shows that diffusion through the swelled polymeric chains is the leading mechanism for drug release. [ABSTRACT FROM AUTHOR]
ISSN:00143057
DOI:10.1016/j.eurpolymj.2016.08.029