Spectroscopic and calorimetric studies on the interaction between PAMAM G4-OH and 5-fluorouracil in aqueous solutions.
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| Title: | Spectroscopic and calorimetric studies on the interaction between PAMAM G4-OH and 5-fluorouracil in aqueous solutions. |
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| Authors: | Buczkowski, Adam1 buczkowski_adam@tlen.pl, Urbaniak, Pawel2, Piekarski, Henryk1, Palecz, Bartlomiej1 paleczb@uni.lodz.pl |
| Source: | Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy. Jan2017, Vol. 171, p401-405. 5p. |
| Subjects: | Calorimetry, Aqueous solutions, Fluorouracil, Hydroxyl group, Nuclear magnetic resonance spectroscopy |
| Abstract: | The results of spectroscopic measurements (an increase in solubility, equilibrium dialysis, 1 H NMR titration) and calorimetric measurements (isothermal titration ITC) indicate spontaneous ( ΔG < 0) binding of 5-fluorouracil molecules by PAMAM G4-OH dendrimer with terminal hydroxyl groups in an aqueous solution. PAMAM G4-OH dendrimer bonds about n = 8 ± 1 molecules of the drug with an equilibrium constant of K = 70 ± 10. The process of saturating the dendrimer active sites by the drug molecules is exothermal ( ΔH < 0) and is accompanied by an advantageous change in entropy ( ΔS > 0). The parameters of binding 5-fluorouracil by PAMAM G4-OH dendrimer were compared with those of binding this drug by the macromolecules of PAMAM G3-OH and G5-OH. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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