View in EDS

Dissolution Dynamic Nuclear Polarization capability study with fluid path.

Saved in:
Bibliographic Details
Title: Dissolution Dynamic Nuclear Polarization capability study with fluid path.
Authors: Malinowski, Ronja M.1, Lipsø, Kasper W.1, Lerche, Mathilde H.1,2, Ardenkjær-Larsen, Jan H.1,3 jhar@elektro.dtu.dk
Source: Journal of Magnetic Resonance. Nov2016, Vol. 272, p141-146. 6p.
Subjects: Magnetic resonance imaging of cancer, Polarization (Nuclear physics), Solvents, Pyruvates, Standard deviations
Abstract: Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden of the hyperpolarized product is by use of a closed fluid path that constitutes a barrier to contamination. The fluid path can be filled with the pharmaceuticals, i.e. imaging agent and solvents, in a clean room, and then stored or immediately used at the polarizer. In this study, we present a method of filling the fluid path that allows it to be reused. The filling method has been investigated in terms of reproducibility at two extrema, high dose for patient use and low dose for rodent studies, using [1-13C]pyruvate as example. We demonstrate that the filling method allows high reproducibility of six quality control parameters with standard deviations 3–10 times smaller than the acceptance criteria intervals in clinical studies. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Magnetic Resonance is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden of the hyperpolarized product is by use of a closed fluid path that constitutes a barrier to contamination. The fluid path can be filled with the pharmaceuticals, i.e. imaging agent and solvents, in a clean room, and then stored or immediately used at the polarizer. In this study, we present a method of filling the fluid path that allows it to be reused. The filling method has been investigated in terms of reproducibility at two extrema, high dose for patient use and low dose for rodent studies, using [1-13C]pyruvate as example. We demonstrate that the filling method allows high reproducibility of six quality control parameters with standard deviations 3–10 times smaller than the acceptance criteria intervals in clinical studies. [ABSTRACT FROM AUTHOR]
ISSN:10907807
DOI:10.1016/j.jmr.2016.09.015