Bibliographic Details
| Title: |
Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes. |
| Authors: |
Belli Dell’ Amico, Daniela1, Labella, Luca1, Marchetti, Fabio1, Samaritani, Simona1 simona.samaritani@unipi.it, Hernández-Fuentes, Gustavo Alejandro2,3, García-Argáez, Aída Nelly3,4, Dalla Via, Lisa3 |
| Source: |
Polyhedron. Nov2016, Vol. 119, p396-402. 7p. |
| Subjects: |
Metal complexes, Complex compounds synthesis, Platinum compounds, Triphenylphosphine, Phenanthroline, Dehalogenation |
| Abstract: |
Ionic platinum(II) complexes [PtCl(PPh 3 )(L∧L)][BF 4 ] {L∧L = 2,2′-bipyridyl ( 1 ) 1,10-phenanthroline ( 2 )} and [PtCl(PPh 3 )(L) 2 ][BF 4 ] {L = pyridine ( 3 ), dimethyl sulfoxide ( 4 )} were synthesized by dehalogenation of cis- [PtCl 2 (PPh 3 )(NCMe)], followed by reaction with the suitable ligand. Chelating nitrogen ligands L∧L afforded single products, which were structurally characterized. In the other cases mixtures of geometric (L = pyridine) and/or coordination (L = dimethyl sulfoxide) isomers were observed in solution. In these cases the structures of the less soluble isomers were obtained via single crystal X-ray diffraction. All the complexes were tested in vitro for their antiproliferative activity on three human tumor cell lines: MSTO-211H, HeLa and HepG2. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
