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Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes.

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Title: Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes.
Authors: Belli Dell’ Amico, Daniela1, Labella, Luca1, Marchetti, Fabio1, Samaritani, Simona1 simona.samaritani@unipi.it, Hernández-Fuentes, Gustavo Alejandro2,3, García-Argáez, Aída Nelly3,4, Dalla Via, Lisa3
Source: Polyhedron. Nov2016, Vol. 119, p396-402. 7p.
Subjects: Metal complexes, Complex compounds synthesis, Platinum compounds, Triphenylphosphine, Phenanthroline, Dehalogenation
Abstract: Ionic platinum(II) complexes [PtCl(PPh 3 )(L∧L)][BF 4 ] {L∧L = 2,2′-bipyridyl ( 1 ) 1,10-phenanthroline ( 2 )} and [PtCl(PPh 3 )(L) 2 ][BF 4 ] {L = pyridine ( 3 ), dimethyl sulfoxide ( 4 )} were synthesized by dehalogenation of cis- [PtCl 2 (PPh 3 )(NCMe)], followed by reaction with the suitable ligand. Chelating nitrogen ligands L∧L afforded single products, which were structurally characterized. In the other cases mixtures of geometric (L = pyridine) and/or coordination (L = dimethyl sulfoxide) isomers were observed in solution. In these cases the structures of the less soluble isomers were obtained via single crystal X-ray diffraction. All the complexes were tested in vitro for their antiproliferative activity on three human tumor cell lines: MSTO-211H, HeLa and HepG2. [ABSTRACT FROM AUTHOR]
Copyright of Polyhedron is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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An: 119604513
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  Data: Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes.
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  Data: <searchLink fieldCode="JN" term="%22Polyhedron%22">Polyhedron</searchLink>. Nov2016, Vol. 119, p396-402. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Metal+complexes%22">Metal complexes</searchLink><br /><searchLink fieldCode="DE" term="%22Complex+compounds+synthesis%22">Complex compounds synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Platinum+compounds%22">Platinum compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Triphenylphosphine%22">Triphenylphosphine</searchLink><br /><searchLink fieldCode="DE" term="%22Phenanthroline%22">Phenanthroline</searchLink><br /><searchLink fieldCode="DE" term="%22Dehalogenation%22">Dehalogenation</searchLink>
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  Data: Ionic platinum(II) complexes [PtCl(PPh 3 )(L∧L)][BF 4 ] {L∧L = 2,2′-bipyridyl ( 1 ) 1,10-phenanthroline ( 2 )} and [PtCl(PPh 3 )(L) 2 ][BF 4 ] {L = pyridine ( 3 ), dimethyl sulfoxide ( 4 )} were synthesized by dehalogenation of cis- [PtCl 2 (PPh 3 )(NCMe)], followed by reaction with the suitable ligand. Chelating nitrogen ligands L∧L afforded single products, which were structurally characterized. In the other cases mixtures of geometric (L = pyridine) and/or coordination (L = dimethyl sulfoxide) isomers were observed in solution. In these cases the structures of the less soluble isomers were obtained via single crystal X-ray diffraction. All the complexes were tested in vitro for their antiproliferative activity on three human tumor cell lines: MSTO-211H, HeLa and HepG2. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Polyhedron is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.poly.2016.09.019
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      – Code: eng
        Text: English
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        PageCount: 7
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      – SubjectFull: Metal complexes
        Type: general
      – SubjectFull: Complex compounds synthesis
        Type: general
      – SubjectFull: Platinum compounds
        Type: general
      – SubjectFull: Triphenylphosphine
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      – SubjectFull: Phenanthroline
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      – SubjectFull: Dehalogenation
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      – TitleFull: Synthesis and antiproliferative activity of ionic platinum(II) triphenylphosphino complexes.
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              Text: Nov2016
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