Solvation behaviour of some amino acids in aqueous solutions of an antibiotic drug streptomycin sulfate at different temperatures: Volumetric, acoustic and viscometric approach.
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| Title: | Solvation behaviour of some amino acids in aqueous solutions of an antibiotic drug streptomycin sulfate at different temperatures: Volumetric, acoustic and viscometric approach. |
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| Authors: | Rani, Ruby1, Kumar, Ashwani1, Bamezai, Rajinder K.1 rkbamezai@gmail.com |
| Source: | Journal of Molecular Liquids. Dec2016 Part B, Vol. 224, p1142-1153. 12p. |
| Subjects: | Solvation, Amino acids, Aqueous solutions, Antibiotics, Streptomycin, Temperature effect, Viscometry |
| Abstract: | The volumetric, acoustic and viscometric approach has been used for investigating the interactions of l -serine, l -threonine and l -leucine in aqueous solutions of an antimycobacterial drug, namely, streptomycin sulfate, over a temperature range of (305.15, 310.15 and 315.15) K at atmospheric pressure. The apparent molar volume, V ϕ , limiting apparent molar volume, V 0 ϕ , the slope, S v , partial molar volume of transfer, V 0 ϕ , tr , limiting apparent molar expansivity, E 0 ϕ , and Hepler's constant, ( ∂ 2 V 0 ϕ / ∂ T 2 ) P , have been calculated from density data. The apparent molar isentropic compression, K ϕ , s , limiting apparent molar isentropic compression, K 0 ϕ , s , its slope, S k , and partial molar isentropic compression of transfer, K 0 ϕ , s , tr , have been calculated from speed of sound data. The compression data is also used for calculating the number of water molecules hydrated, n H , to the amino acids. The viscosity data has been used to determine relative viscosity η r , viscosity B -coefficients, temperature derivative of B -coefficients, dB/dT and viscosity B -coefficients of transfer, B tr . Solvation behaviour, of amino acids has also been computed. The calculated parameters have been discussed in terms of various solute–solute and solute–solvent interactions prevailing in these solutions. Further, a detailed insight into the physicochemical interactions, e.g., ion-hydrophilic and hydrophilic–hydrophilic interactions in the amino acids in conjunction with the drug along with the structure-making/structure-breaking tendency has been retrieved through the perusal of these calculated parameters. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
| Abstract: | The volumetric, acoustic and viscometric approach has been used for investigating the interactions of l -serine, l -threonine and l -leucine in aqueous solutions of an antimycobacterial drug, namely, streptomycin sulfate, over a temperature range of (305.15, 310.15 and 315.15) K at atmospheric pressure. The apparent molar volume, V ϕ , limiting apparent molar volume, V 0 ϕ , the slope, S v , partial molar volume of transfer, V 0 ϕ , tr , limiting apparent molar expansivity, E 0 ϕ , and Hepler's constant, ( ∂ 2 V 0 ϕ / ∂ T 2 ) P , have been calculated from density data. The apparent molar isentropic compression, K ϕ , s , limiting apparent molar isentropic compression, K 0 ϕ , s , its slope, S k , and partial molar isentropic compression of transfer, K 0 ϕ , s , tr , have been calculated from speed of sound data. The compression data is also used for calculating the number of water molecules hydrated, n H , to the amino acids. The viscosity data has been used to determine relative viscosity η r , viscosity B -coefficients, temperature derivative of B -coefficients, dB/dT and viscosity B -coefficients of transfer, B tr . Solvation behaviour, of amino acids has also been computed. The calculated parameters have been discussed in terms of various solute–solute and solute–solvent interactions prevailing in these solutions. Further, a detailed insight into the physicochemical interactions, e.g., ion-hydrophilic and hydrophilic–hydrophilic interactions in the amino acids in conjunction with the drug along with the structure-making/structure-breaking tendency has been retrieved through the perusal of these calculated parameters. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01677322 |
| DOI: | 10.1016/j.molliq.2016.10.063 |
