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A combined study of MEG and pico-Tesla TMS on children with autism disorder.

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Title: A combined study of MEG and pico-Tesla TMS on children with autism disorder.
Authors: Anninos, Photios1, Chatzimichael, Athanasios2, Adamopoulos, Adam1, Kotini, Athanasia1, Tsagas, Nicolaos3
Source: Journal of Integrative Neuroscience. Dec2016, Vol. 15 Issue 4, p497-513. 17p.
Subjects: Diagnosis of autism in children, Transcranial magnetic stimulation, Magnetoencephalography, Magnetic noise, Magnetic fields
Abstract: Magnetoencephalographic (MEG) recordings from the brain of 10 children with autism (6 boys and 4 girls, with ages range from 5-12 years, meanSD: 8.32.1) were obtained using a whole-head 122-channel MEG system in a magnetically shielded room of low magnetic noise. A double-blind experimental design was used in order to look for possible effect of external pico-Tesla Transcranial Magnetic Stimulation (pT-TMS). The pT-TMS was applied on the brain of the autistic children with proper field characteristics (magnetic field amplitude: 1-7.5pT, frequency: the alpha - rhythm of the patient 8-13Hz). After unblinding it was found a significant effect of an increase of frequencies in the range of 2-7Hz across the subjects followed by an improvement and normalization of their MEG recordings. The statistical analysis of our results showed a statistical significance at 6 out of 10 patients (60%). It is also observed an increase of alpha activity in autistic children at the end of one month after pT-TMS treatment at home. In conclusion, the application of pT-TMS has the prospective to be a noninvasive, safe and important modality in the management of autism children. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Magnetoencephalographic (MEG) recordings from the brain of 10 children with autism (6 boys and 4 girls, with ages range from 5-12 years, meanSD: 8.32.1) were obtained using a whole-head 122-channel MEG system in a magnetically shielded room of low magnetic noise. A double-blind experimental design was used in order to look for possible effect of external pico-Tesla Transcranial Magnetic Stimulation (pT-TMS). The pT-TMS was applied on the brain of the autistic children with proper field characteristics (magnetic field amplitude: 1-7.5pT, frequency: the alpha - rhythm of the patient 8-13Hz). After unblinding it was found a significant effect of an increase of frequencies in the range of 2-7Hz across the subjects followed by an improvement and normalization of their MEG recordings. The statistical analysis of our results showed a statistical significance at 6 out of 10 patients (60%). It is also observed an increase of alpha activity in autistic children at the end of one month after pT-TMS treatment at home. In conclusion, the application of pT-TMS has the prospective to be a noninvasive, safe and important modality in the management of autism children. [ABSTRACT FROM AUTHOR]
ISSN:02196352
DOI:10.1142/S0219635216500278