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Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles.

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Title:	Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles.
Authors:	York-Duran, M.J.¹, Godoy-Gallardo, M.¹, Labay, C.¹, Urquhart, A.J.¹, Andresen, T.L.¹, Hosta-Rigau, L.¹ leri@nanotech.dtu.dk
Source:	Colloids & Surfaces B: Biointerfaces. Apr2017, Vol. 152, p199-213. 15p.
Subjects:	Drug carriers, Organelles, Cell compartmentation, Cell metabolism, Microreactors
Abstract:	Compartmentalization is a key feature of biological cells which conduct their metabolic activity in individual steps isolated in distinct, separated compartments. The creation of architectures containing multiple compartments with a structure that resembles that of a biological cell has generated significant research attention and these assemblies are proposed as candidate materials for a range of biomedical applications. In this Review article, the recent successes of multicompartment architectures as carriers for the delivery of therapeutic cargo or the creation of micro- and nanoreactors that mimic metabolic activities, thus acting as artificial cells or organelles, are discussed. The developed technologies to assemble such complex architectures are outlined, the multicompartment carriers’ properties which contribute to their performance in diverse applications are discussed, and their successful applications are highlighted. Finally, future directions and developments in the field are suggested. [ABSTRACT FROM AUTHOR]
	Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Engineering Source

Description
Abstract:	Compartmentalization is a key feature of biological cells which conduct their metabolic activity in individual steps isolated in distinct, separated compartments. The creation of architectures containing multiple compartments with a structure that resembles that of a biological cell has generated significant research attention and these assemblies are proposed as candidate materials for a range of biomedical applications. In this Review article, the recent successes of multicompartment architectures as carriers for the delivery of therapeutic cargo or the creation of micro- and nanoreactors that mimic metabolic activities, thus acting as artificial cells or organelles, are discussed. The developed technologies to assemble such complex architectures are outlined, the multicompartment carriers’ properties which contribute to their performance in diverse applications are discussed, and their successful applications are highlighted. Finally, future directions and developments in the field are suggested. [ABSTRACT FROM AUTHOR]
ISSN:	09277765
DOI:	10.1016/j.colsurfb.2017.01.014