View in EDS

Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles.

Saved in:
Bibliographic Details
Title: Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles.
Authors: York-Duran, M.J.1, Godoy-Gallardo, M.1, Labay, C.1, Urquhart, A.J.1, Andresen, T.L.1, Hosta-Rigau, L.1 leri@nanotech.dtu.dk
Source: Colloids & Surfaces B: Biointerfaces. Apr2017, Vol. 152, p199-213. 15p.
Subjects: Drug carriers, Organelles, Cell compartmentation, Cell metabolism, Microreactors
Abstract: Compartmentalization is a key feature of biological cells which conduct their metabolic activity in individual steps isolated in distinct, separated compartments. The creation of architectures containing multiple compartments with a structure that resembles that of a biological cell has generated significant research attention and these assemblies are proposed as candidate materials for a range of biomedical applications. In this Review article, the recent successes of multicompartment architectures as carriers for the delivery of therapeutic cargo or the creation of micro- and nanoreactors that mimic metabolic activities, thus acting as artificial cells or organelles, are discussed. The developed technologies to assemble such complex architectures are outlined, the multicompartment carriers’ properties which contribute to their performance in diverse applications are discussed, and their successful applications are highlighted. Finally, future directions and developments in the field are suggested. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 121672106
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22York-Duran%2C+M%2EJ%2E%22">York-Duran, M.J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Godoy-Gallardo%2C+M%2E%22">Godoy-Gallardo, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Labay%2C+C%2E%22">Labay, C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Urquhart%2C+A%2EJ%2E%22">Urquhart, A.J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Andresen%2C+T%2EL%2E%22">Andresen, T.L.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hosta-Rigau%2C+L%2E%22">Hosta-Rigau, L.</searchLink><relatesTo>1</relatesTo><i> leri@nanotech.dtu.dk</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. Apr2017, Vol. 152, p199-213. 15p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Drug+carriers%22">Drug carriers</searchLink><br /><searchLink fieldCode="DE" term="%22Organelles%22">Organelles</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+compartmentation%22">Cell compartmentation</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+metabolism%22">Cell metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Microreactors%22">Microreactors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Compartmentalization is a key feature of biological cells which conduct their metabolic activity in individual steps isolated in distinct, separated compartments. The creation of architectures containing multiple compartments with a structure that resembles that of a biological cell has generated significant research attention and these assemblies are proposed as candidate materials for a range of biomedical applications. In this Review article, the recent successes of multicompartment architectures as carriers for the delivery of therapeutic cargo or the creation of micro- and nanoreactors that mimic metabolic activities, thus acting as artificial cells or organelles, are discussed. The developed technologies to assemble such complex architectures are outlined, the multicompartment carriers’ properties which contribute to their performance in diverse applications are discussed, and their successful applications are highlighted. Finally, future directions and developments in the field are suggested. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=121672106
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.colsurfb.2017.01.014
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 199
    Subjects:
      – SubjectFull: Drug carriers
        Type: general
      – SubjectFull: Organelles
        Type: general
      – SubjectFull: Cell compartmentation
        Type: general
      – SubjectFull: Cell metabolism
        Type: general
      – SubjectFull: Microreactors
        Type: general
    Titles:
      – TitleFull: Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: York-Duran, M.J.
      – PersonEntity:
          Name:
            NameFull: Godoy-Gallardo, M.
      – PersonEntity:
          Name:
            NameFull: Labay, C.
      – PersonEntity:
          Name:
            NameFull: Urquhart, A.J.
      – PersonEntity:
          Name:
            NameFull: Andresen, T.L.
      – PersonEntity:
          Name:
            NameFull: Hosta-Rigau, L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 09277765
          Numbering:
            – Type: volume
              Value: 152
          Titles:
            – TitleFull: Colloids & Surfaces B: Biointerfaces
              Type: main
ResultId 1