Bibliographic Details
| Title: |
The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data |
| Authors: |
Chakravarti, Arnab1 achakravarti@partners.org, Dicker, Adam2, Mehta, Minesh3 |
| Source: |
International Journal of Radiation Oncology, Biology, Physics. Mar2004, Vol. 58 Issue 3, p927. 5p. |
| Subjects: |
Epidermal growth factor, Gliomas, Radiation, Nervous system tumors |
| Abstract: |
: PurposeThe epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII).: Methods and materialsThis review highlights EGFR''s role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data.: ResultsPreclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas.: ConclusionsTargeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients. [Copyright &y& Elsevier] |
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Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Engineering Source |
