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The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data

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Title: The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data
Authors: Chakravarti, Arnab1 achakravarti@partners.org, Dicker, Adam2, Mehta, Minesh3
Source: International Journal of Radiation Oncology, Biology, Physics. Mar2004, Vol. 58 Issue 3, p927. 5p.
Subjects: Epidermal growth factor, Gliomas, Radiation, Nervous system tumors
Abstract: : PurposeThe epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII).: Methods and materialsThis review highlights EGFR''s role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data.: ResultsPreclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas.: ConclusionsTargeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients. [Copyright &y& Elsevier]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 12171653
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
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  Data: The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Chakravarti%2C+Arnab%22">Chakravarti, Arnab</searchLink><relatesTo>1</relatesTo><i> achakravarti@partners.org</i><br /><searchLink fieldCode="AR" term="%22Dicker%2C+Adam%22">Dicker, Adam</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Mehta%2C+Minesh%22">Mehta, Minesh</searchLink><relatesTo>3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Mar2004, Vol. 58 Issue 3, p927. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Epidermal+growth+factor%22">Epidermal growth factor</searchLink><br /><searchLink fieldCode="DE" term="%22Gliomas%22">Gliomas</searchLink><br /><searchLink fieldCode="DE" term="%22Radiation%22">Radiation</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system+tumors%22">Nervous system tumors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: : PurposeThe epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII).: Methods and materialsThis review highlights EGFR''s role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data.: ResultsPreclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas.: ConclusionsTargeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.ijrobp.2003.09.092
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 927
    Subjects:
      – SubjectFull: Epidermal growth factor
        Type: general
      – SubjectFull: Gliomas
        Type: general
      – SubjectFull: Radiation
        Type: general
      – SubjectFull: Nervous system tumors
        Type: general
    Titles:
      – TitleFull: The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data
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            NameFull: Chakravarti, Arnab
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            NameFull: Dicker, Adam
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            NameFull: Mehta, Minesh
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              Text: Mar2004
              Type: published
              Y: 2004
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              Value: 58
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          Titles:
            – TitleFull: International Journal of Radiation Oncology, Biology, Physics
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