Effects of viscosity on droplet formation and mixing in microfluidic channels
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| Title: | Effects of viscosity on droplet formation and mixing in microfluidic channels |
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| Authors: | Tice, Joshua D.1, Lyon, Adam D.1, Ismagilov, Rustem F. r-ismagilov@uchicago.edu |
| Source: | Analytica Chimica Acta. Apr2004, Vol. 507 Issue 1, p73. 5p. |
| Subjects: | Viscosity, Crystallization, Proteins |
| Abstract: | This paper characterizes the conditions required to form nanoliter-sized droplets (plugs) of viscous aqueous reagents in flows of immiscible carrier fluid within microfluidic channels. For both non-viscous (viscosity of 2.0 mPa s) and viscous (viscosity of 18 mPa s) aqueous solutions, plugs formed reliably in a flow of water-immiscible carrier fluid for Capillary number less than 0.01, although plugs were able to form at higher Capillary numbers at lower ratios of the aqueous phase flow rate to the flow rate of the carrier fluid (in all the experiments performed, the Reynolds number was less than 1). The paper also shows that combining viscous and non-viscous reagents can enhance mixing in droplets moving through straight microchannels by providing a nearly ideal initial distribution of reagents within each droplet. The study should facilitate the use of this droplet-based microfluidic platform for investigation of protein crystallization, kinetics, and assays. [Copyright &y& Elsevier] |
| Copyright of Analytica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 12235737 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of viscosity on droplet formation and mixing in microfluidic channels – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tice%2C+Joshua+D%2E%22">Tice, Joshua D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lyon%2C+Adam+D%2E%22">Lyon, Adam D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ismagilov%2C+Rustem+F%2E%22">Ismagilov, Rustem F.</searchLink><i> r-ismagilov@uchicago.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Analytica+Chimica+Acta%22">Analytica Chimica Acta</searchLink>. Apr2004, Vol. 507 Issue 1, p73. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Viscosity%22">Viscosity</searchLink><br /><searchLink fieldCode="DE" term="%22Crystallization%22">Crystallization</searchLink><br /><searchLink fieldCode="DE" term="%22Proteins%22">Proteins</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This paper characterizes the conditions required to form nanoliter-sized droplets (plugs) of viscous aqueous reagents in flows of immiscible carrier fluid within microfluidic channels. For both non-viscous (viscosity of 2.0 mPa s) and viscous (viscosity of 18 mPa s) aqueous solutions, plugs formed reliably in a flow of water-immiscible carrier fluid for Capillary number less than 0.01, although plugs were able to form at higher Capillary numbers at lower ratios of the aqueous phase flow rate to the flow rate of the carrier fluid (in all the experiments performed, the Reynolds number was less than 1). The paper also shows that combining viscous and non-viscous reagents can enhance mixing in droplets moving through straight microchannels by providing a nearly ideal initial distribution of reagents within each droplet. The study should facilitate the use of this droplet-based microfluidic platform for investigation of protein crystallization, kinetics, and assays. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Analytica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=12235737 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.aca.2003.11.024 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 73 Subjects: – SubjectFull: Viscosity Type: general – SubjectFull: Crystallization Type: general – SubjectFull: Proteins Type: general Titles: – TitleFull: Effects of viscosity on droplet formation and mixing in microfluidic channels Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tice, Joshua D. – PersonEntity: Name: NameFull: Lyon, Adam D. – PersonEntity: Name: NameFull: Ismagilov, Rustem F. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00032670 Numbering: – Type: volume Value: 507 – Type: issue Value: 1 Titles: – TitleFull: Analytica Chimica Acta Type: main |
| ResultId | 1 |
