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Amplification of Hofmeister effect on poly(n-isopropylacrylamide) by crown ether.

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Title: Amplification of Hofmeister effect on poly(n-isopropylacrylamide) by crown ether.
Authors: Reddy, P. Madhusudhana1, Hsieh, Shih-Rong2, Chang, Chi-Jung1 changcj@fcu.edu.tw, Leong, Yun-Yi1, Chen, Jem-Kun3, Lee, Ming-Ching2
Source: Colloids & Surfaces A: Physicochemical & Engineering Aspects. Sep2017, Vol. 528, p1-9. 9p.
Subjects: Crown ethers, Anions, Ethers, Ions, Permeability
Abstract: Indeed, the relative strength of specific ion effect on macromolecule/biomacromolecules increases with increasing concentration. However, the utilization of high ion concentration may lead to aggregation or precipitation of macromolecule/biomacromolecule. Therefore, in the present study, we provided a potential alternative method to tune the strengths of “salting-in” and “salting-out” effects of Hofmeister series anions on the coil-globule transition of poly( N -isopropylacrylamide) (PNIPAM) by using a crown ether, 18-crown-6 (18-C-6) as a crowding agent. The ionic liquids (ILs) having the same cation, 1-butyl-3-methylimidazolium (Bmim + ) and commonly used anions such as CH 3 COO − , Cl − and I − were selected to explore the strengths of “salting-in” and “salting-out” effects of Hofmeister series anions on a coil-globule transition of PNIPAM in the crowded environment of 18-C-6. Our experimental results (differential scanning calorimetry, hydrodynamic radius, fluoresce intensity, Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy) demonstrated that the salting-out effect exerted by a kosmotropic anion, CH 3 COO − , is strengthened, while the salting-in effect exerted by a chaotropic anion, I − , is weakened in the presence of 18-C-6. The results from the present study may certainly provide an alternative method to tune the relative strength of Hofmeister effect without increasing salt concentration. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Indeed, the relative strength of specific ion effect on macromolecule/biomacromolecules increases with increasing concentration. However, the utilization of high ion concentration may lead to aggregation or precipitation of macromolecule/biomacromolecule. Therefore, in the present study, we provided a potential alternative method to tune the strengths of “salting-in” and “salting-out” effects of Hofmeister series anions on the coil-globule transition of poly( N -isopropylacrylamide) (PNIPAM) by using a crown ether, 18-crown-6 (18-C-6) as a crowding agent. The ionic liquids (ILs) having the same cation, 1-butyl-3-methylimidazolium (Bmim + ) and commonly used anions such as CH 3 COO − , Cl − and I − were selected to explore the strengths of “salting-in” and “salting-out” effects of Hofmeister series anions on a coil-globule transition of PNIPAM in the crowded environment of 18-C-6. Our experimental results (differential scanning calorimetry, hydrodynamic radius, fluoresce intensity, Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy) demonstrated that the salting-out effect exerted by a kosmotropic anion, CH 3 COO − , is strengthened, while the salting-in effect exerted by a chaotropic anion, I − , is weakened in the presence of 18-C-6. The results from the present study may certainly provide an alternative method to tune the relative strength of Hofmeister effect without increasing salt concentration. [ABSTRACT FROM AUTHOR]
ISSN:09277757
DOI:10.1016/j.colsurfa.2017.05.037