Bibliographic Details
| Title: |
N-Acyl-2-benzoxazolinones in titanium-mediated aldol reactions |
| Authors: |
Burlingame, Mark A. burlingame@kosan.com, Mendoza, Esteban1, Ashley, Gary W.1 |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2004, Vol. 45 Issue 14, p2961. 4p. |
| Subjects: |
Titanium compounds, Aldehydes, Esters, Aldol condensation |
| Abstract: |
N-Acyl-2-benzoxazolinones readily form trichlorotitanium enolates that react rapidly with aldehydes to provide crystalline syn-aldol adducts in high yield. The resulting products are simply converted to amides, esters, and thioesters. A simple, economical synthesis of 3-hydroxy-2-methylpentanoate N-propionylcysteamine thioesters based on these findings is presented. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
