Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects.
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| Title: | Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects. |
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| Authors: | Yang, Taowei1,2 (AUTHOR), Rao, Zhiming1,2 (AUTHOR) raozhm@jiangnan.edu.cn, Zhang, Xian1 (AUTHOR), Xu, Meijuan1 (AUTHOR), Xu, Zhenghong3 (AUTHOR), Yang, Shang-Tian4 (AUTHOR) |
| Source: | Critical Reviews in Biotechnology. Dec2017, Vol. 37 Issue 8, p990-1005. 16p. |
| Subjects: | Acetoin, Butanediol manufacturing, Systems biology, Synthetic biology, Bacterial metabolites |
| Abstract: | Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology. [ABSTRACT FROM PUBLISHER] |
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| Database: | Engineering Source |
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| Abstract: | Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology. [ABSTRACT FROM PUBLISHER] |
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| ISSN: | 07388551 |
| DOI: | 10.1080/07388551.2017.1299680 |
