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Rapid prototyping of whole-thermoplastic microfluidics with built-in microvalves using laser ablation and thermal fusion bonding.

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Title: Rapid prototyping of whole-thermoplastic microfluidics with built-in microvalves using laser ablation and thermal fusion bonding.
Authors: Shaegh, Seyed Ali Mousavi1,2,3, Pourmand, Adel1,2,4, Nabavinia, Mahboubeh1,2,5, Avci, Huseyin1,2,6, Tamayol, Ali1,2,7, Mostafalu, Pooria1,2,7, Ghavifekr, Habib Badri4, Aghdam, Esmaeil Najafi4, Dokmeci, Mehmet Remzi1,2,7, Khademhosseini, Ali1,2,7,8,9,10 alik@bwh.harvard.edu, Zhang, Yu Shrike1,2,7 yszhang@research.bwh.harvard.edu
Source: Sensors & Actuators B: Chemical. Feb2018 Part 1, Vol. 255, p100-109. 10p.
Subjects: Rapid prototyping, Microfluidic devices, Laser ablation, Fusion (Phase transformation), Robust control, Deformations (Mechanics)
Abstract: Recently, there has been an increasing effort in developing new fabrication methods for rapid prototyping of microfluidic chips using thermoplastic materials. This is mainly due to the excellent properties of thermoplastics including inherent robustness to mechanical deformation and resistance to chemicals. In this paper, we report on the development of a novel rapid prototyping method to fabricate microfluidic chips from thermoplastic materials with embedded pneumatic controls. A CO 2 laser micromachining method was employed to engrave and cut poly(methyl methacrylate) (PMMA) sheets, which together with a thermoplastic polyurethane (TPU) film, enabled fabrication of various functional microfluidic elements including microvalves, micropumps, and bioreactors. To generate the gas-actuated microvalve, unfocused CO 2 laser beam was used to fabricate semi-circular fluid channels in PMMA. An optimized chemical surface treatment procedure was subsequently applied to smoothen the surface of the microchannels. TPU film serving as a flexible membrane was attached above the semi-circular channel sandwiched by another piece of PMMA containing a gas channel to achieve the architecture of the microvalve. A thermal fusion bonding method was developed to bond TPU film to the PMMA components in a single step. A peristaltic micropump was also fabricated consisting of sequential interconnected gas-actuated microvalves. In addition, results from cell cultures in fabricated whole-thermoplastic bioreactors demonstrated biocompatibility of the whole-thermoplastic microchips. Taken together, the developed fabrication process in conjunction with proposed thermoplastic materials provide an inexpensive and versatile method for rapid prototyping of various microfluidic devices. [ABSTRACT FROM AUTHOR]
Copyright of Sensors & Actuators B: Chemical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 125806321
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  Data: Rapid prototyping of whole-thermoplastic microfluidics with built-in microvalves using laser ablation and thermal fusion bonding.
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  Data: <searchLink fieldCode="AR" term="%22Shaegh%2C+Seyed+Ali+Mousavi%22">Shaegh, Seyed Ali Mousavi</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Pourmand%2C+Adel%22">Pourmand, Adel</searchLink><relatesTo>1,2,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Nabavinia%2C+Mahboubeh%22">Nabavinia, Mahboubeh</searchLink><relatesTo>1,2,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Avci%2C+Huseyin%22">Avci, Huseyin</searchLink><relatesTo>1,2,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Tamayol%2C+Ali%22">Tamayol, Ali</searchLink><relatesTo>1,2,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Mostafalu%2C+Pooria%22">Mostafalu, Pooria</searchLink><relatesTo>1,2,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Ghavifekr%2C+Habib+Badri%22">Ghavifekr, Habib Badri</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Aghdam%2C+Esmaeil+Najafi%22">Aghdam, Esmaeil Najafi</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Dokmeci%2C+Mehmet+Remzi%22">Dokmeci, Mehmet Remzi</searchLink><relatesTo>1,2,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Khademhosseini%2C+Ali%22">Khademhosseini, Ali</searchLink><relatesTo>1,2,7,8,9,10</relatesTo><i> alik@bwh.harvard.edu</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yu+Shrike%22">Zhang, Yu Shrike</searchLink><relatesTo>1,2,7</relatesTo><i> yszhang@research.bwh.harvard.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Sensors+%26+Actuators+B%3A+Chemical%22">Sensors & Actuators B: Chemical</searchLink>. Feb2018 Part 1, Vol. 255, p100-109. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Rapid+prototyping%22">Rapid prototyping</searchLink><br /><searchLink fieldCode="DE" term="%22Microfluidic+devices%22">Microfluidic devices</searchLink><br /><searchLink fieldCode="DE" term="%22Laser+ablation%22">Laser ablation</searchLink><br /><searchLink fieldCode="DE" term="%22Fusion+%28Phase+transformation%29%22">Fusion (Phase transformation)</searchLink><br /><searchLink fieldCode="DE" term="%22Robust+control%22">Robust control</searchLink><br /><searchLink fieldCode="DE" term="%22Deformations+%28Mechanics%29%22">Deformations (Mechanics)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Recently, there has been an increasing effort in developing new fabrication methods for rapid prototyping of microfluidic chips using thermoplastic materials. This is mainly due to the excellent properties of thermoplastics including inherent robustness to mechanical deformation and resistance to chemicals. In this paper, we report on the development of a novel rapid prototyping method to fabricate microfluidic chips from thermoplastic materials with embedded pneumatic controls. A CO 2 laser micromachining method was employed to engrave and cut poly(methyl methacrylate) (PMMA) sheets, which together with a thermoplastic polyurethane (TPU) film, enabled fabrication of various functional microfluidic elements including microvalves, micropumps, and bioreactors. To generate the gas-actuated microvalve, unfocused CO 2 laser beam was used to fabricate semi-circular fluid channels in PMMA. An optimized chemical surface treatment procedure was subsequently applied to smoothen the surface of the microchannels. TPU film serving as a flexible membrane was attached above the semi-circular channel sandwiched by another piece of PMMA containing a gas channel to achieve the architecture of the microvalve. A thermal fusion bonding method was developed to bond TPU film to the PMMA components in a single step. A peristaltic micropump was also fabricated consisting of sequential interconnected gas-actuated microvalves. In addition, results from cell cultures in fabricated whole-thermoplastic bioreactors demonstrated biocompatibility of the whole-thermoplastic microchips. Taken together, the developed fabrication process in conjunction with proposed thermoplastic materials provide an inexpensive and versatile method for rapid prototyping of various microfluidic devices. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Sensors & Actuators B: Chemical is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.snb.2017.07.138
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 100
    Subjects:
      – SubjectFull: Rapid prototyping
        Type: general
      – SubjectFull: Microfluidic devices
        Type: general
      – SubjectFull: Laser ablation
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      – SubjectFull: Fusion (Phase transformation)
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      – SubjectFull: Robust control
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      – SubjectFull: Deformations (Mechanics)
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              Text: Feb2018 Part 1
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