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Association between phthalate exposure and lower lung function in an urban elderly population: A repeated-measures longitudinal study.

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Title: Association between phthalate exposure and lower lung function in an urban elderly population: A repeated-measures longitudinal study.
Authors: Kim, Kyoung-Nam1,2, Lee, Mee-Ri2, Choi, Yoon-Hyeong3, Lee, Bo-Eun4, Hong, Yun-Chul2,5,6 ychong1@snu.ac.kr
Source: Environment International. Apr2018, Vol. 113, p177-183. 7p.
Subjects: Environmental exposure, Physiological effects of phthalate esters, Lung physiology, Health of older people, Pulmonary function tests, Metabolites
Abstract: Background Lung function is a major predictor of morbidity and mortality. Only a few studies have explored the association between phthalate exposure and lung function. Objective To evaluate the association between phthalate exposure and lung function in the elderly. Methods A total of 3 repeated-measures surveys were conducted in 559 elderly individuals aged ≥60 years in Seoul, Korea, at 1-year intervals (2012–2015). During each survey, urinary mono-(2-ethyl-5-hydrohexyl) phthalate (MEHHP) (geometric mean, 15.68 μg/L), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (11.97 μg/L), and mono- n -butyl phthalate (MnBP) (2.09 μg/L) levels were measured; moreover, lung function tests and a structured questionnaire interview were performed. We constructed linear mixed models to assess the association between urinary phthalate metabolite levels and lung function. Results A doubling of creatinine-adjusted urinary phthalate metabolite levels was inversely associated with forced expiratory volume in 1 s (L) (β = −0.01, 95% confidence interval [CI]: −0.02, 0.004 for MEHHP; β = −0.02, 95% CI: −0.03, −0.01 for MEOHP; β = −0.01, 95% CI: −0.03, −0.003 for MnBP) and forced vital capacity (L) (β = −0.02, 95% CI: −0.03, −0.001 for MEHHP; β = −0.02, 95% CI: −0.03, −0.004 for MEOHP; β = −0.02, 95% CI: −0.03, −0.001 for MnBP). A doubling of creatinine-adjusted MnBP levels was associated with increased rates of annual decline in forced vital capacity (L/year) (β = −0.01, 95% CI: −0.02, −0.001). Conclusions Urinary phthalate metabolite levels were associated with lower lung function and an increased rate of decline in lung function in an elderly population. [ABSTRACT FROM AUTHOR]
Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Association between phthalate exposure and lower lung function in an urban elderly population: A repeated-measures longitudinal study.
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  Data: <searchLink fieldCode="AR" term="%22Kim%2C+Kyoung-Nam%22">Kim, Kyoung-Nam</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Mee-Ri%22">Lee, Mee-Ri</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Choi%2C+Yoon-Hyeong%22">Choi, Yoon-Hyeong</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Bo-Eun%22">Lee, Bo-Eun</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Hong%2C+Yun-Chul%22">Hong, Yun-Chul</searchLink><relatesTo>2,5,6</relatesTo><i> ychong1@snu.ac.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Environment+International%22">Environment International</searchLink>. Apr2018, Vol. 113, p177-183. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+phthalate+esters%22">Physiological effects of phthalate esters</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+physiology%22">Lung physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Health+of+older+people%22">Health of older people</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+function+tests%22">Pulmonary function tests</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolites%22">Metabolites</searchLink>
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  Data: Background Lung function is a major predictor of morbidity and mortality. Only a few studies have explored the association between phthalate exposure and lung function. Objective To evaluate the association between phthalate exposure and lung function in the elderly. Methods A total of 3 repeated-measures surveys were conducted in 559 elderly individuals aged ≥60 years in Seoul, Korea, at 1-year intervals (2012–2015). During each survey, urinary mono-(2-ethyl-5-hydrohexyl) phthalate (MEHHP) (geometric mean, 15.68 μg/L), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (11.97 μg/L), and mono- n -butyl phthalate (MnBP) (2.09 μg/L) levels were measured; moreover, lung function tests and a structured questionnaire interview were performed. We constructed linear mixed models to assess the association between urinary phthalate metabolite levels and lung function. Results A doubling of creatinine-adjusted urinary phthalate metabolite levels was inversely associated with forced expiratory volume in 1 s (L) (β = −0.01, 95% confidence interval [CI]: −0.02, 0.004 for MEHHP; β = −0.02, 95% CI: −0.03, −0.01 for MEOHP; β = −0.01, 95% CI: −0.03, −0.003 for MnBP) and forced vital capacity (L) (β = −0.02, 95% CI: −0.03, −0.001 for MEHHP; β = −0.02, 95% CI: −0.03, −0.004 for MEOHP; β = −0.02, 95% CI: −0.03, −0.001 for MnBP). A doubling of creatinine-adjusted MnBP levels was associated with increased rates of annual decline in forced vital capacity (L/year) (β = −0.01, 95% CI: −0.02, −0.001). Conclusions Urinary phthalate metabolite levels were associated with lower lung function and an increased rate of decline in lung function in an elderly population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Environment International is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.envint.2018.02.004
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        Type: general
      – SubjectFull: Physiological effects of phthalate esters
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      – SubjectFull: Lung physiology
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      – SubjectFull: Health of older people
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      – SubjectFull: Pulmonary function tests
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      – SubjectFull: Metabolites
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      – TitleFull: Association between phthalate exposure and lower lung function in an urban elderly population: A repeated-measures longitudinal study.
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              Text: Apr2018
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