Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways.
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| Title: | Protective effect of dietary fiber from sweet potato (Ipomoea batatas L.) against lead‐induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways. |
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| Authors: | Zhang, Yi1, Gu, WenLong2, Duan, LiQin2, Zhu, Hong1, Wang, HongYun1, Wang, Jing2, Sun, Jian1 xzsunjian@jaas.ac.cn, Niu, FuXiang1 niufuxiang@sina.com |
| Source: | Journal of Food Biochemistry. Jun2018, Vol. 42 Issue 3, p1-1. 11p. |
| Subjects: | Dietary fiber, Sweet potatoes, Kidney diseases, Oxidative stress, Laboratory mice |
| Abstract: | Abstract: Dietary fiber (DF) is the main component of sweet potato residue, which has a variety of health benefits. However, the preventive effect of DF from sweet potato on lead (Pb)‐induced renal injury remains unclear. This study identified the proximate composition and chemical components of DF extracted by ultrasound‐assisted enzymatic hydrolysis. The administration of ordinary dietary fiber (ODF) and high‐soluble dietary fiber (HSDF) decreased the blood and kidney Pb concentrations of Pb‐exposed mice. Moreover, profound Pb‐induced elevations of reactive oxygen species, malondialdehyde level, and depletion of intracellular glutathione level in kidney were suppressed by treatment with HSDF. Compared to the ODF group, HSDF activated AMP‐activated protein kinase (AMPK)/silent information regulator T1 (SIRT1)/peroxisome proliferator‐activated receptor‐γ coactivator 1α (PGC1α) signaling in kidney, which directly regulates superoxide dismutase (SOD) and nuclear respiratory factors (NRF1)/mitochondrial transcription factor A (TFAM). In conclusion, HSDF supplementation ameliorates Pb‐induced renal injury by inhibiting oxidative stress. Practical applications: In China, sweet potato residue is discarded as waste, which causes environmental pollution. Sweet potato residue can be a cheap and widely available resource of DF, which was extracted by ultrasound‐assisted enzymatic hydrolysis. This study provides biological evidence that supports the use of DF from sweet potato to prevent Pb accumulation and protect the kidney, thereby indicating that DF has a great potential to be used as natural Pb‐excreting agent and functional ingredient in food products. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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