Bibliographic Details
| Title: |
High-throughput single-cell transcriptomics on organoids. |
| Authors: |
Brazovskaja, Agnieska1, Treutlein, Barbara1,2,3 barbara_treutlein@eva.mpg.de, Camp, J Gray1 gray_camp@eva.mpg.de |
| Source: |
Current Opinion in Biotechnology. Feb2019, Vol. 55, p167-171. 5p. |
| Subjects: |
Organoids, Human stem cells, Nucleotide sequence, Transcriptomes, Genomics, Individualized medicine |
| Abstract: |
Three-dimensional (3D) tissues grown in culture from human stem cells offer the incredible opportunity to analyze and manipulate human development, and to generate patient-specific models of disease. Methods to sequence DNA and RNA in single cells are being used to analyze these so-called 'organoid' systems in high-resolution. Single-cell transcriptomics has been used to quantitate the similarity of organoid cells to primary tissue counterparts in the brain, intestine, liver, and kidney, as well as identify cell-specific responses to environmental variables and disease conditions. The merging of these two technologies, single-cell genomics and organoids, will have profound impact on personalized medicine in the near future. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
