High-throughput single-cell transcriptomics on organoids.
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| Title: | High-throughput single-cell transcriptomics on organoids. |
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| Authors: | Brazovskaja, Agnieska1, Treutlein, Barbara1,2,3 barbara_treutlein@eva.mpg.de, Camp, J Gray1 gray_camp@eva.mpg.de |
| Source: | Current Opinion in Biotechnology. Feb2019, Vol. 55, p167-171. 5p. |
| Subjects: | Organoids, Human stem cells, Nucleotide sequence, Transcriptomes, Genomics, Individualized medicine |
| Abstract: | Three-dimensional (3D) tissues grown in culture from human stem cells offer the incredible opportunity to analyze and manipulate human development, and to generate patient-specific models of disease. Methods to sequence DNA and RNA in single cells are being used to analyze these so-called 'organoid' systems in high-resolution. Single-cell transcriptomics has been used to quantitate the similarity of organoid cells to primary tissue counterparts in the brain, intestine, liver, and kidney, as well as identify cell-specific responses to environmental variables and disease conditions. The merging of these two technologies, single-cell genomics and organoids, will have profound impact on personalized medicine in the near future. [ABSTRACT FROM AUTHOR] |
| Copyright of Current Opinion in Biotechnology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 134617071 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.copbio.2018.11.002 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 167 Subjects: – SubjectFull: Organoids Type: general – SubjectFull: Human stem cells Type: general – SubjectFull: Nucleotide sequence Type: general – SubjectFull: Transcriptomes Type: general – SubjectFull: Genomics Type: general – SubjectFull: Individualized medicine Type: general Titles: – TitleFull: High-throughput single-cell transcriptomics on organoids. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Brazovskaja, Agnieska – PersonEntity: Name: NameFull: Treutlein, Barbara – PersonEntity: Name: NameFull: Camp, J Gray IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 09581669 Numbering: – Type: volume Value: 55 Titles: – TitleFull: Current Opinion in Biotechnology Type: main |
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