Bibliographic Details
| Title: |
Copper-Catalysed Hydroamination of N -Allenylsulfonamides: The Key Role of Ancillary Coordinating Groups. |
| Authors: |
Blieck, Rémi1 florian.monnier@enscm.fr, Perego, Luca Alessandro2,3 laurence.grimaud@ens.fr, Ciofini, Ilaria3, Grimaud, Laurence2, Taillefer, Marc1 marc.taillefer@enscm.fr, Monnier, Florian1,4 |
| Source: |
Synthesis. 2019, Vol. 51 Issue 5, p1225-1234. 10p. |
| Subjects: |
Copper catalysts, Copper, Hydroamination, Addition reactions, Catalysts |
| Abstract: |
A copper-catalysed hydroamination reaction of N -allenylsulfonamides with amines has been developed through a rational approach based on mechanistic studies. The reaction is promoted by a simple copper(I) catalyst and proceeds at room temperature with complete regioselectivity and excellent stereoselectivity towards linear (E)- N -(3-aminoprop-1-enyl)sulfonamides. Density Functional Theory (DFT) studies allow interpreting the key role of unsaturated substituents on nitrogen as ancillary coordinating moieties for the copper catalyst. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
