View in EDS

A facile strategy to fabricate a pH-responsive mesoporous silica nanoparticle end-capped with amphiphilic peptides by self-assembly.

Saved in:
Bibliographic Details
Title: A facile strategy to fabricate a pH-responsive mesoporous silica nanoparticle end-capped with amphiphilic peptides by self-assembly.
Authors: Zhao, Fengfeng1 (AUTHOR), Zhang, Chen1 (AUTHOR), Zhao, Chenggui1 (AUTHOR), Gao, Wei1 (AUTHOR), Fan, Xiaobo2 (AUTHOR), Wu, Guoqiu1,2 (AUTHOR) nationball@163.com
Source: Colloids & Surfaces B: Biointerfaces. Jul2019, Vol. 179, p352-362. 11p.
Subjects: Targeted drug delivery, Controlled release drugs, Drug delivery systems, Peptides, Silica nanoparticles
Abstract: • Amphiphilic peptide (P45) operated smart nanovalves by self-assembly in the presence of Dox. • The obtained nanoparticles were simple but smart with no modification. • Targeted drug delivery and pH sensitive drug release. • The obtained nanoparticles showed enhanced cellular uptake and higher anti-cancer effect. A facile strategy with no modification processes was demonstrated to fabricate a pH-responsive end-capped mesoporous silica nanoparticle (MSN)-based drug delivery system (DDS). The simple but smart nanovalve systems were constructed by the self-assembly behavior of unbonded peptide-based amphiphile (P45) in the presence of Doxorubicin hydrochloride (Dox). A series of characterizations confirmed that the DDSs had been successfully fabricated. Dox molecules were entrapped by nanovalves in the pores of MSNs, and an in vitro release experiment demonstrated that the P45/Dox@MSNs exhibited "zero premature release" in the physical environment. However, an accelerated release was triggered by an acidic atmosphere in cellular cytosol. Moreover, detailed investigations confirmed that the enhanced cellular uptake of P45/Dox@MSNs due to the RGD motif of the nanovalves, exhibiting an obvious toxicity to cancer cells. Therefore, the DDSs constructed here can serve as a promising platform to realize targeted drug delivery and controlled drug release by using diversified bioactive native amphiphilic peptide. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:• Amphiphilic peptide (P45) operated smart nanovalves by self-assembly in the presence of Dox. • The obtained nanoparticles were simple but smart with no modification. • Targeted drug delivery and pH sensitive drug release. • The obtained nanoparticles showed enhanced cellular uptake and higher anti-cancer effect. A facile strategy with no modification processes was demonstrated to fabricate a pH-responsive end-capped mesoporous silica nanoparticle (MSN)-based drug delivery system (DDS). The simple but smart nanovalve systems were constructed by the self-assembly behavior of unbonded peptide-based amphiphile (P45) in the presence of Doxorubicin hydrochloride (Dox). A series of characterizations confirmed that the DDSs had been successfully fabricated. Dox molecules were entrapped by nanovalves in the pores of MSNs, and an in vitro release experiment demonstrated that the P45/Dox@MSNs exhibited "zero premature release" in the physical environment. However, an accelerated release was triggered by an acidic atmosphere in cellular cytosol. Moreover, detailed investigations confirmed that the enhanced cellular uptake of P45/Dox@MSNs due to the RGD motif of the nanovalves, exhibiting an obvious toxicity to cancer cells. Therefore, the DDSs constructed here can serve as a promising platform to realize targeted drug delivery and controlled drug release by using diversified bioactive native amphiphilic peptide. [ABSTRACT FROM AUTHOR]
ISSN:09277765
DOI:10.1016/j.colsurfb.2019.03.019