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TRPC3 channels confer cellular memory of recent neuromuscular activity.

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Title: TRPC3 channels confer cellular memory of recent neuromuscular activity.
Authors: Rosenberg, Paul1, Hawkins, April1, Stiber, Jonathan1, Shelton, John M.2, Hutcheson, Kelley1, Bassel-Duby, Rhonda2, Shin, Dong Min3, Yan, Zhen1, Williams, R. Sanders1 rosen029@mc.duke.edu
Source: Proceedings of the National Academy of Sciences of the United States of America. 6/22/2004, Vol. 101 Issue 25, p9387-9392. 6p.
Subjects: Systemic memory hypothesis, Neuroplasticity, Gene expression, T cells, Muscles, Proteins
Abstract: Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work demands (muscle plasticity). Calcineurin, a calcium/calmodulin dependent, serine-threonine protein phosphatase, has been shown to control programs of gene expression in skeletal muscles, as in other cell types, through the transcription factor nuclear factor of activated T cells (NFAT). This study provides evidence that the function of NEAT as a transcriptional activator is regulated by neuromuscular stimulation in muscles of intact animals and that calcium influx from the transient receptor potential (TRPC3) channel is an important determinant of NFAT activity. Expression of TRPC3 channels in skeletal myocytes is upregulated by neuromuscular activity in a calcineurin-dependent manner. These data suggest a mechanism for cellular memory in skeletal muscles whereby repeated bouts of contractile activity drive progressively greater remodeling events. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work demands (muscle plasticity). Calcineurin, a calcium/calmodulin dependent, serine-threonine protein phosphatase, has been shown to control programs of gene expression in skeletal muscles, as in other cell types, through the transcription factor nuclear factor of activated T cells (NFAT). This study provides evidence that the function of NEAT as a transcriptional activator is regulated by neuromuscular stimulation in muscles of intact animals and that calcium influx from the transient receptor potential (TRPC3) channel is an important determinant of NFAT activity. Expression of TRPC3 channels in skeletal myocytes is upregulated by neuromuscular activity in a calcineurin-dependent manner. These data suggest a mechanism for cellular memory in skeletal muscles whereby repeated bouts of contractile activity drive progressively greater remodeling events. [ABSTRACT FROM AUTHOR]
ISSN:00278424
DOI:10.1073/pnas.0308179101