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Novel secoeunicellins produced by an octocoral Cladiella sp.

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Title: Novel secoeunicellins produced by an octocoral Cladiella sp.
Authors: Zhang, Zhi-Jun1,2 (AUTHOR), Wang, Yi-Hsuan1,3 (AUTHOR), Chen, Shu-Rong4 (AUTHOR), Peng, Bo-Rong2 (AUTHOR), Yang, San-Nan5 (AUTHOR), Hu, Chiung-Chih2 (AUTHOR), Fang, Lee-Shing6,7 (AUTHOR), Hwang, Tsong-Long1,3,8,9,10 (AUTHOR) htl@mail.cgu.edu.tw, Sung, Ping-Jyun1,2,4,11,12 (AUTHOR) pjsung@nmmba.gov.tw
Source: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2019, Vol. 60 Issue 49, pN.PAG-N.PAG. 1p.
Subjects: Methoxy group, Superoxides
Abstract: • New 6,7-secoeunicellins, cladieunicellins W (1) and X (2), were obtained from Cladiella sp. • Secoeunicellin 2 displayed significant anti-inflammatory activity. • A methoxy group played an important role in determining the activity. Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:• New 6,7-secoeunicellins, cladieunicellins W (1) and X (2), were obtained from Cladiella sp. • Secoeunicellin 2 displayed significant anti-inflammatory activity. • A methoxy group played an important role in determining the activity. Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds. [ABSTRACT FROM AUTHOR]
ISSN:00404039
DOI:10.1016/j.tetlet.2019.151300