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Enhancing the sensitivity of point-of-use electrochemical microfluidic sensors by ion concentration polarisation – A case study on arsenic.

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Title: Enhancing the sensitivity of point-of-use electrochemical microfluidic sensors by ion concentration polarisation – A case study on arsenic.
Authors: Subramanian, Vidhya1,2 (AUTHOR), Lee, Sangjun3 (AUTHOR), Jena, Sanjoy4 (AUTHOR), Jana, Sourav Kanti1 (AUTHOR), Ray, Debdutta4 (AUTHOR), Kim, Sung Jae3,5,6 (AUTHOR), Thalappil, Pradeep1 (AUTHOR) pradeep@iitm.ac.in
Source: Sensors & Actuators B: Chemical. Feb2020, Vol. 304, pN.PAG-N.PAG. 1p.
Subjects: Electrochemical sensors, Microfluidic devices, Water quality monitoring, Fluidics, Labs on a chip, Arsenic, Metal detectors, Arsenic compounds
Geographic Terms: India
Abstract: • First report of utilising Ion Concentration Polarisation for concentrating ions in a microfluidic device. • Facile fabrication technique for the development of multiple layer Lab on a Chip device without the use of valves. • Detection of As3+ to 1 ppb without surface modification of the working electrode. • Detection of 7 ppb of As3+ in field sample without any pre-treatment of the sample. Point of use (POU) sensors are extremely relevant, being capable of providing fast and reliable analysis in remote and resource-limited settings. Of all the diverse techniques utilised for POU sensors, a combination of electrochemistry and microfluidics may have the greatest potential towards quantitative assessment of heavy metal ions. The major challenge in combining these for sensing applications lies in the complexity of fabricating integrated devices and the insufficient quantity of analytes in the sample volume. To address these issues, we have developed a radial microfluidic device capable of electrokinetic preconcentration by ion concentration polarization (ICP) and integrated it with electroactive surfaces. The proposed sensor is the first demonstration of concentration of heavy metal ions by ICP and its quantitative assessment by voltammetry. Utilising the integrated sensor, we have shown the sensing of As3+ down to 1 ppb by linear sweep voltammetry with ∼40 μL of sample. The sensor was also tested successfully for sensing As3+ in a field sample from an arsenic affected region of India. The sensor was also tested for the detection of other metal ions too. This work would facilitate the development of highly sensitive POU hand-held sensors for water quality monitoring in resource-limited areas. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:• First report of utilising Ion Concentration Polarisation for concentrating ions in a microfluidic device. • Facile fabrication technique for the development of multiple layer Lab on a Chip device without the use of valves. • Detection of As3+ to 1 ppb without surface modification of the working electrode. • Detection of 7 ppb of As3+ in field sample without any pre-treatment of the sample. Point of use (POU) sensors are extremely relevant, being capable of providing fast and reliable analysis in remote and resource-limited settings. Of all the diverse techniques utilised for POU sensors, a combination of electrochemistry and microfluidics may have the greatest potential towards quantitative assessment of heavy metal ions. The major challenge in combining these for sensing applications lies in the complexity of fabricating integrated devices and the insufficient quantity of analytes in the sample volume. To address these issues, we have developed a radial microfluidic device capable of electrokinetic preconcentration by ion concentration polarization (ICP) and integrated it with electroactive surfaces. The proposed sensor is the first demonstration of concentration of heavy metal ions by ICP and its quantitative assessment by voltammetry. Utilising the integrated sensor, we have shown the sensing of As3+ down to 1 ppb by linear sweep voltammetry with ∼40 μL of sample. The sensor was also tested successfully for sensing As3+ in a field sample from an arsenic affected region of India. The sensor was also tested for the detection of other metal ions too. This work would facilitate the development of highly sensitive POU hand-held sensors for water quality monitoring in resource-limited areas. [ABSTRACT FROM AUTHOR]
ISSN:09254005
DOI:10.1016/j.snb.2019.127340