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Calculation of S-values for head and brain structures from a constructed voxelized phantom for positron-emitting radionuclides.

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Title: Calculation of S-values for head and brain structures from a constructed voxelized phantom for positron-emitting radionuclides.
Authors: Reynoso-Mejía, C.A.1,2 (AUTHOR) betoven@ciencias.unam.mx, Kerik-Rotenberg, N.2 (AUTHOR) nora.kerik@hotmail.com, Moranchel, M.1 (AUTHOR) mmoranchel1508@gmail.com
Source: Radiation Physics & Chemistry. Jan2020, Vol. 166, pN.PAG-N.PAG. 1p.
Subjects: International Commission on Radiological Protection, Radioisotopes, Brain, Monte Carlo method, Positrons, Absorbed dose, Head, Positron emission
Abstract: Stylized and voxelized phantoms have been used to estimate S-values for positron-emitting radionuclides. However, there is a lack of computational phantoms that include head and brain structures of importance for neuroimaging studies, such as brain PET-CT. The aim of this work was to construct a multi-resolution whole-body phantom for Monte Carlo simulations in MCNP code that includes a complete set of head and brain structures. The International Commission on Radiological Protection (ICRP-110) male reference phantom and the Zubal head phantom were used to construct the ICRP-HEAD phantom. This multi-resolution phantom was used to calculate self-absorbed fractions (SAFs) and S-values for seven positron-emitting radionuclides used in PET neuroimaging (C-11, O-15, F-18, Cu-64, I-124, Ga-68, and Y-86). S-values calculated in this work were compared with two head/brain phantoms previously published: the stylized MIRD-15 phantom and the tomographic VIP-Man phantom. The voxel resolution of the phantom resulted well suited for Monte Carlo simulations in MCNP6.2 code. For the same target and source structure, the highest auto absorbed S-values were produced by O-15 and Ga-68, while for different target and source structures, Y-86 produced the highest S-values. The lowest S-values were produced by Cu-64. Comparison of S-values with those calculated from the MIRD-15 phantom showed significant differences, while a better agreement was found with those calculated from the VIP-Man phantom. The S-values obtained in this work could help to improve the accuracy of absorbed dose in brain and head structures for positron-emitting radionuclides used in PET neuroimaging. • A multi-resolution whole-body phantom was constructed in MCNP code that include a complete set of head and brain structures. • A voxel phantom was constructed based on the ICRP-110 adult male reference phantom and on the Zubal head phantom. • Self-absorbed fractions (self-AFs) and S-values were calculated for seven positron-emitting radionuclides. • The constructed ICRP-head phantom provides a more accurate representation of the head and brain structures. [ABSTRACT FROM AUTHOR]
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Abstract:Stylized and voxelized phantoms have been used to estimate S-values for positron-emitting radionuclides. However, there is a lack of computational phantoms that include head and brain structures of importance for neuroimaging studies, such as brain PET-CT. The aim of this work was to construct a multi-resolution whole-body phantom for Monte Carlo simulations in MCNP code that includes a complete set of head and brain structures. The International Commission on Radiological Protection (ICRP-110) male reference phantom and the Zubal head phantom were used to construct the ICRP-HEAD phantom. This multi-resolution phantom was used to calculate self-absorbed fractions (SAFs) and S-values for seven positron-emitting radionuclides used in PET neuroimaging (C-11, O-15, F-18, Cu-64, I-124, Ga-68, and Y-86). S-values calculated in this work were compared with two head/brain phantoms previously published: the stylized MIRD-15 phantom and the tomographic VIP-Man phantom. The voxel resolution of the phantom resulted well suited for Monte Carlo simulations in MCNP6.2 code. For the same target and source structure, the highest auto absorbed S-values were produced by O-15 and Ga-68, while for different target and source structures, Y-86 produced the highest S-values. The lowest S-values were produced by Cu-64. Comparison of S-values with those calculated from the MIRD-15 phantom showed significant differences, while a better agreement was found with those calculated from the VIP-Man phantom. The S-values obtained in this work could help to improve the accuracy of absorbed dose in brain and head structures for positron-emitting radionuclides used in PET neuroimaging. • A multi-resolution whole-body phantom was constructed in MCNP code that include a complete set of head and brain structures. • A voxel phantom was constructed based on the ICRP-110 adult male reference phantom and on the Zubal head phantom. • Self-absorbed fractions (self-AFs) and S-values were calculated for seven positron-emitting radionuclides. • The constructed ICRP-head phantom provides a more accurate representation of the head and brain structures. [ABSTRACT FROM AUTHOR]
ISSN:0969806X
DOI:10.1016/j.radphyschem.2019.108427