Deformation of human red blood cells in extensional flow through a hyperbolic contraction.

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Bibliographic Details
Title:	Deformation of human red blood cells in extensional flow through a hyperbolic contraction.
Authors:	Faghih, Mohammad M.¹ (AUTHOR), Sharp, M. Keith¹ (AUTHOR) keith.sharp@louisville.edu
Source:	Biomechanics & Modeling in Mechanobiology. Feb2020, Vol. 19 Issue 1, p251-261. 11p.
Subjects:	Erythrocytes, Shearing force, Damage models, Erythrocyte deformability
Abstract:	Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the fluid stress tensor. However, the expanded models were not validated by measurements of damage in response to the added types of stress. Recent investigations have proposed that extensional stress might be more damaging to red cells than shear stress. In this study, experiments were conducted to compare human red cell deformation under laminar extensional stress versus laminar shear stress. It was found that the deformation caused by shear stress is matched by that produced by an extensional stress that is approximately 34 times smaller. Assuming that blood damage scales directly with cell deformation, this result indicates that mechanistic blood damage prediction models should weigh extensional stress more than shear stress. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the fluid stress tensor. However, the expanded models were not validated by measurements of damage in response to the added types of stress. Recent investigations have proposed that extensional stress might be more damaging to red cells than shear stress. In this study, experiments were conducted to compare human red cell deformation under laminar extensional stress versus laminar shear stress. It was found that the deformation caused by shear stress is matched by that produced by an extensional stress that is approximately 34 times smaller. Assuming that blood damage scales directly with cell deformation, this result indicates that mechanistic blood damage prediction models should weigh extensional stress more than shear stress. [ABSTRACT FROM AUTHOR]
ISSN:	16177959
DOI:	10.1007/s10237-019-01208-3