Deformation of human red blood cells in extensional flow through a hyperbolic contraction.
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| Title: | Deformation of human red blood cells in extensional flow through a hyperbolic contraction. |
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| Authors: | Faghih, Mohammad M.1 (AUTHOR), Sharp, M. Keith1 (AUTHOR) keith.sharp@louisville.edu |
| Source: | Biomechanics & Modeling in Mechanobiology. Feb2020, Vol. 19 Issue 1, p251-261. 11p. |
| Subjects: | Erythrocytes, Shearing force, Damage models, Erythrocyte deformability |
| Abstract: | Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the fluid stress tensor. However, the expanded models were not validated by measurements of damage in response to the added types of stress. Recent investigations have proposed that extensional stress might be more damaging to red cells than shear stress. In this study, experiments were conducted to compare human red cell deformation under laminar extensional stress versus laminar shear stress. It was found that the deformation caused by shear stress is matched by that produced by an extensional stress that is approximately 34 times smaller. Assuming that blood damage scales directly with cell deformation, this result indicates that mechanistic blood damage prediction models should weigh extensional stress more than shear stress. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 141578856 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Deformation of human red blood cells in extensional flow through a hyperbolic contraction. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Faghih%2C+Mohammad+M%2E%22">Faghih, Mohammad M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharp%2C+M%2E+Keith%22">Sharp, M. Keith</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> keith.sharp@louisville.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomechanics+%26+Modeling+in+Mechanobiology%22">Biomechanics & Modeling in Mechanobiology</searchLink>. Feb2020, Vol. 19 Issue 1, p251-261. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Erythrocytes%22">Erythrocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Shearing+force%22">Shearing force</searchLink><br /><searchLink fieldCode="DE" term="%22Damage+models%22">Damage models</searchLink><br /><searchLink fieldCode="DE" term="%22Erythrocyte+deformability%22">Erythrocyte deformability</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Flow-induced damage to red blood cells has been an issue of considerable importance since the introduction of the first cardiovascular devices. Early blood damage prediction models were based on measurements of damage by shear stress only. Subsequently, these models were extrapolated to include other components of the fluid stress tensor. However, the expanded models were not validated by measurements of damage in response to the added types of stress. Recent investigations have proposed that extensional stress might be more damaging to red cells than shear stress. In this study, experiments were conducted to compare human red cell deformation under laminar extensional stress versus laminar shear stress. It was found that the deformation caused by shear stress is matched by that produced by an extensional stress that is approximately 34 times smaller. Assuming that blood damage scales directly with cell deformation, this result indicates that mechanistic blood damage prediction models should weigh extensional stress more than shear stress. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomechanics & Modeling in Mechanobiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10237-019-01208-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 251 Subjects: – SubjectFull: Erythrocytes Type: general – SubjectFull: Shearing force Type: general – SubjectFull: Damage models Type: general – SubjectFull: Erythrocyte deformability Type: general Titles: – TitleFull: Deformation of human red blood cells in extensional flow through a hyperbolic contraction. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Faghih, Mohammad M. – PersonEntity: Name: NameFull: Sharp, M. Keith IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 16177959 Numbering: – Type: volume Value: 19 – Type: issue Value: 1 Titles: – TitleFull: Biomechanics & Modeling in Mechanobiology Type: main |
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