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Characterization of 9 gas chromatography columns by Kovats and Lee retention indices for dioxin analysis.

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Title: Characterization of 9 gas chromatography columns by Kovats and Lee retention indices for dioxin analysis.
Authors: Stultz, Conner1 (AUTHOR), Dorman, Frank1,2 (AUTHOR) fld3@psu.edu
Source: Journal of Chromatography A. Mar2020, Vol. 1614, pN.PAG-N.PAG. 1p.
Subjects: Polychlorinated dibenzodioxins, Column chromatography, Gas chromatography, Reference sources
Abstract: • Characterization of 9 modern and popular GC columns for dioxin analysis. • Full elution orders for all 136 tetra-octa chlorinated dioxins and furans. • Retention index database for 136 chlorinated dioxins and 32 mixed halogenated dioxins. • Selectivity and orthogonality comparisons for 8 modern GC columns for dioxin analysis. Polychlorinated dibenzo-p-dioxins and furans offer a complex separation challenge due to their chemical similarity and 5020 possible congeners, including the Br/Cl congeners. Not only are these compounds difficult to separate, but they are also difficult to identify. Expensive reference materials are needed for conventional "dioxin analysis", usually requiring 13C labeled and native compounds. A retention index database offers a potential solution to lower the difficulty and cost to identify dioxins. This study describes the use of Kovats and Lee retention indices for the identification of chlorinated dioxins and furans as well as their brominated and mixed chloro/bromo counterparts. Eight columns were characterized with all 136 tetra through octa substituted chlorinated dioxins and furans as well as 32 brominated and mixed chloro/bromo congeners. Columns were then compared to identify which stationary phases provided the best resolution for critical congeners, like the 2,3,7,8 substituted compounds. Column phase selectivity was also investigated to identify best commercially-available column pairings for confirmatory analyses and GC × GC separations. The Rtx-Dioxin2 and Rxi-17SilMS showed unique selectivity for dioxins and furans and could be used as confirmatory columns or as a powerful GC × GC column set. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:• Characterization of 9 modern and popular GC columns for dioxin analysis. • Full elution orders for all 136 tetra-octa chlorinated dioxins and furans. • Retention index database for 136 chlorinated dioxins and 32 mixed halogenated dioxins. • Selectivity and orthogonality comparisons for 8 modern GC columns for dioxin analysis. Polychlorinated dibenzo-p-dioxins and furans offer a complex separation challenge due to their chemical similarity and 5020 possible congeners, including the Br/Cl congeners. Not only are these compounds difficult to separate, but they are also difficult to identify. Expensive reference materials are needed for conventional "dioxin analysis", usually requiring 13C labeled and native compounds. A retention index database offers a potential solution to lower the difficulty and cost to identify dioxins. This study describes the use of Kovats and Lee retention indices for the identification of chlorinated dioxins and furans as well as their brominated and mixed chloro/bromo counterparts. Eight columns were characterized with all 136 tetra through octa substituted chlorinated dioxins and furans as well as 32 brominated and mixed chloro/bromo congeners. Columns were then compared to identify which stationary phases provided the best resolution for critical congeners, like the 2,3,7,8 substituted compounds. Column phase selectivity was also investigated to identify best commercially-available column pairings for confirmatory analyses and GC × GC separations. The Rtx-Dioxin2 and Rxi-17SilMS showed unique selectivity for dioxins and furans and could be used as confirmatory columns or as a powerful GC × GC column set. [ABSTRACT FROM AUTHOR]
ISSN:00219673
DOI:10.1016/j.chroma.2019.460701