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Needle-Type Imager Sensor With Band-Pass Composite Emission Filter and Parallel Fiber-Coupled Laser Excitation.

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Bibliographic Details
Title: Needle-Type Imager Sensor With Band-Pass Composite Emission Filter and Parallel Fiber-Coupled Laser Excitation.
Authors: Rustami, Erus1 (AUTHOR) erus.rustami.em9@ms.naist.jp, Sasagawa, Kiyotaka1 (AUTHOR) sasagawa@ms.naist.jp, Sugie, Kenji1 (AUTHOR) sugie.kenji.sb5@ms.naist.jp, Ohta, Yasumi1 (AUTHOR) ohtay@ms.naist.jp, Haruta, Makito1 (AUTHOR) m-haruta@ms.naist.jp, Noda, Toshihiko2 (AUTHOR) noda-t@eiiris.tut.ac.jp, Tokuda, Takashi3 (AUTHOR) tokuda@ee.e.titech.ac.jp, Ohta, Jun1 (AUTHOR) ohta@ms.naist.jp
Source: IEEE Transactions on Circuits & Systems. Part I: Regular Papers. Apr2020, Vol. 67 Issue 4, p1082-1091. 10p.
Subjects: Green fluorescent protein, Fiber lasers, Lasers, Filters & filtration, Optical fibers, Composite structures
Abstract: This paper presents an implantable fluorescence system with a composite emission filter and fiber-coupled laser excitation. The composite structure of the short-pass interference filter and absorption filters exhibited a band-pass spectrum between 510 and 570 nm, which is close to green fluorescent protein (GFP) emission. A high-quality excitation light was achieved by utilizing a blue laser through a low-numerical-aperture optical fiber. This coupling method is beneficial in delivering a narrow spectrum and controllable irradiation light in a specific area to minimize auto-fluorescence from the tissue. The fabricated lensless system performance is experimentally validated by imaging emission. The proposed device is capable of perceiving fluorescence emission from microspheres and GFP noticeably. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:This paper presents an implantable fluorescence system with a composite emission filter and fiber-coupled laser excitation. The composite structure of the short-pass interference filter and absorption filters exhibited a band-pass spectrum between 510 and 570 nm, which is close to green fluorescent protein (GFP) emission. A high-quality excitation light was achieved by utilizing a blue laser through a low-numerical-aperture optical fiber. This coupling method is beneficial in delivering a narrow spectrum and controllable irradiation light in a specific area to minimize auto-fluorescence from the tissue. The fabricated lensless system performance is experimentally validated by imaging emission. The proposed device is capable of perceiving fluorescence emission from microspheres and GFP noticeably. [ABSTRACT FROM AUTHOR]
ISSN:15498328
DOI:10.1109/TCSI.2019.2959592