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Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid.

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Bibliographic Details
Title:	Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid.
Authors:	Joshi, Arti¹ (AUTHOR), Gupta, Ruby¹ (AUTHOR), Singh, Bharti² (AUTHOR), Sharma, Deepika¹ (AUTHOR), Singh, Monika¹ (AUTHOR) monika@inst.ac.in
Source:	Dalton Transactions: An International Journal of Inorganic Chemistry. 6/7/2020, Vol. 49 Issue 21, p7069-7077. 9p.
Subjects:	Cancer cells, Hydrogen bonding interactions, Cell death, Liver cancer, Single crystals, Cell cycle, Necrosis, Molybdenum compounds
Abstract:	A novel Strandberg type polyoxomolybdate based organic–inorganic hybrid solid, [{4,4′-H2bpy}{4,4′-Hbpy}2{H2P2Mo5O23}]·5H2O (1) has been synthesized and structurally characterized by the single crystal X-ray diffraction technique. The structure consists of a discrete type phosphomolybdate cluster, [H2P2Mo5O23]4−, connected with three protonated 4,4′-bipyridine molecules by strong hydrogen bonding interactions. The In vitro anti-tumoral activity of compound (1) was tested against human breast cancer (MCF-7), human lung cancer (A549) and human liver cancer (HepG2) cells. The Strandberg type cluster was used against the MCF-7 and A549 cancer cells for the first time hitherto. It shows considerable inhibitory effect with IC50 values of 33.79 μmol L−1, 25.17 μmol L−1, and 32.11 μmol L−1 against HepG2, A549 and MCF-7 respectively. The anti-tumoral activity of 1 was also found to be comparable with that of a routinely used chemotherapeutic agent, methotrexate (MTX), with an IC50 value of 42.03 μmol L−1 for HepG2, 26.93 μmol L−1 for A549 and 49.79 μmol L−1 for MCF-7. The anti-proliferation activity is mediated by the arrest of the A549 and HepG2 cells in the S phase and MCF-7 in the G2/M phase of the cell cycle as suggested by flow cytometry. Results suggest that apoptosis and necrosis pathways ultimately lead to the death of the cancer cells. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	A novel Strandberg type polyoxomolybdate based organic–inorganic hybrid solid, [{4,4′-H2bpy}{4,4′-Hbpy}2{H2P2Mo5O23}]·5H2O (1) has been synthesized and structurally characterized by the single crystal X-ray diffraction technique. The structure consists of a discrete type phosphomolybdate cluster, [H2P2Mo5O23]4−, connected with three protonated 4,4′-bipyridine molecules by strong hydrogen bonding interactions. The In vitro anti-tumoral activity of compound (1) was tested against human breast cancer (MCF-7), human lung cancer (A549) and human liver cancer (HepG2) cells. The Strandberg type cluster was used against the MCF-7 and A549 cancer cells for the first time hitherto. It shows considerable inhibitory effect with IC50 values of 33.79 μmol L−1, 25.17 μmol L−1, and 32.11 μmol L−1 against HepG2, A549 and MCF-7 respectively. The anti-tumoral activity of 1 was also found to be comparable with that of a routinely used chemotherapeutic agent, methotrexate (MTX), with an IC50 value of 42.03 μmol L−1 for HepG2, 26.93 μmol L−1 for A549 and 49.79 μmol L−1 for MCF-7. The anti-proliferation activity is mediated by the arrest of the A549 and HepG2 cells in the S phase and MCF-7 in the G2/M phase of the cell cycle as suggested by flow cytometry. Results suggest that apoptosis and necrosis pathways ultimately lead to the death of the cancer cells. [ABSTRACT FROM AUTHOR]
ISSN:	14779226
DOI:	10.1039/d0dt01042a