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Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid.

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Title: Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid.
Authors: Joshi, Arti1 (AUTHOR), Gupta, Ruby1 (AUTHOR), Singh, Bharti2 (AUTHOR), Sharma, Deepika1 (AUTHOR), Singh, Monika1 (AUTHOR) monika@inst.ac.in
Source: Dalton Transactions: An International Journal of Inorganic Chemistry. 6/7/2020, Vol. 49 Issue 21, p7069-7077. 9p.
Subjects: Cancer cells, Hydrogen bonding interactions, Cell death, Liver cancer, Single crystals, Cell cycle, Necrosis, Molybdenum compounds
Abstract: A novel Strandberg type polyoxomolybdate based organic–inorganic hybrid solid, [{4,4′-H2bpy}{4,4′-Hbpy}2{H2P2Mo5O23}]·5H2O (1) has been synthesized and structurally characterized by the single crystal X-ray diffraction technique. The structure consists of a discrete type phosphomolybdate cluster, [H2P2Mo5O23]4−, connected with three protonated 4,4′-bipyridine molecules by strong hydrogen bonding interactions. The In vitro anti-tumoral activity of compound (1) was tested against human breast cancer (MCF-7), human lung cancer (A549) and human liver cancer (HepG2) cells. The Strandberg type cluster was used against the MCF-7 and A549 cancer cells for the first time hitherto. It shows considerable inhibitory effect with IC50 values of 33.79 μmol L−1, 25.17 μmol L−1, and 32.11 μmol L−1 against HepG2, A549 and MCF-7 respectively. The anti-tumoral activity of 1 was also found to be comparable with that of a routinely used chemotherapeutic agent, methotrexate (MTX), with an IC50 value of 42.03 μmol L−1 for HepG2, 26.93 μmol L−1 for A549 and 49.79 μmol L−1 for MCF-7. The anti-proliferation activity is mediated by the arrest of the A549 and HepG2 cells in the S phase and MCF-7 in the G2/M phase of the cell cycle as suggested by flow cytometry. Results suggest that apoptosis and necrosis pathways ultimately lead to the death of the cancer cells. [ABSTRACT FROM AUTHOR]
Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 143550859
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid.
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  Data: <searchLink fieldCode="AR" term="%22Joshi%2C+Arti%22">Joshi, Arti</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta%2C+Ruby%22">Gupta, Ruby</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+Bharti%22">Singh, Bharti</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharma%2C+Deepika%22">Sharma, Deepika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+Monika%22">Singh, Monika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> monika@inst.ac.in</i>
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  Data: <searchLink fieldCode="JN" term="%22Dalton+Transactions%3A+An+International+Journal+of+Inorganic+Chemistry%22">Dalton Transactions: An International Journal of Inorganic Chemistry</searchLink>. 6/7/2020, Vol. 49 Issue 21, p7069-7077. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogen+bonding+interactions%22">Hydrogen bonding interactions</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+death%22">Cell death</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+cancer%22">Liver cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Single+crystals%22">Single crystals</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+cycle%22">Cell cycle</searchLink><br /><searchLink fieldCode="DE" term="%22Necrosis%22">Necrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Molybdenum+compounds%22">Molybdenum compounds</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A novel Strandberg type polyoxomolybdate based organic–inorganic hybrid solid, [{4,4′-H2bpy}{4,4′-Hbpy}2{H2P2Mo5O23}]·5H2O (1) has been synthesized and structurally characterized by the single crystal X-ray diffraction technique. The structure consists of a discrete type phosphomolybdate cluster, [H2P2Mo5O23]4−, connected with three protonated 4,4′-bipyridine molecules by strong hydrogen bonding interactions. The In vitro anti-tumoral activity of compound (1) was tested against human breast cancer (MCF-7), human lung cancer (A549) and human liver cancer (HepG2) cells. The Strandberg type cluster was used against the MCF-7 and A549 cancer cells for the first time hitherto. It shows considerable inhibitory effect with IC50 values of 33.79 μmol L−1, 25.17 μmol L−1, and 32.11 μmol L−1 against HepG2, A549 and MCF-7 respectively. The anti-tumoral activity of 1 was also found to be comparable with that of a routinely used chemotherapeutic agent, methotrexate (MTX), with an IC50 value of 42.03 μmol L−1 for HepG2, 26.93 μmol L−1 for A549 and 49.79 μmol L−1 for MCF-7. The anti-proliferation activity is mediated by the arrest of the A549 and HepG2 cells in the S phase and MCF-7 in the G2/M phase of the cell cycle as suggested by flow cytometry. Results suggest that apoptosis and necrosis pathways ultimately lead to the death of the cancer cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1039/d0dt01042a
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 7069
    Subjects:
      – SubjectFull: Cancer cells
        Type: general
      – SubjectFull: Hydrogen bonding interactions
        Type: general
      – SubjectFull: Cell death
        Type: general
      – SubjectFull: Liver cancer
        Type: general
      – SubjectFull: Single crystals
        Type: general
      – SubjectFull: Cell cycle
        Type: general
      – SubjectFull: Necrosis
        Type: general
      – SubjectFull: Molybdenum compounds
        Type: general
    Titles:
      – TitleFull: Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid.
        Type: main
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            NameFull: Joshi, Arti
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            NameFull: Gupta, Ruby
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            NameFull: Singh, Bharti
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            NameFull: Sharma, Deepika
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            NameFull: Singh, Monika
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            – D: 07
              M: 06
              Text: 6/7/2020
              Type: published
              Y: 2020
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              Value: 49
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              Value: 21
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            – TitleFull: Dalton Transactions: An International Journal of Inorganic Chemistry
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