Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[ N -(2-hydroxypropyl)methacrylamide]- Block -Poly[ N -(2,2-difluoroethyl)acrylamide], Prominent 19 F MRI Tracer.
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| Title: | Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[ N -(2-hydroxypropyl)methacrylamide]- Block -Poly[ N -(2,2-difluoroethyl)acrylamide], Prominent 19 F MRI Tracer. |
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| Authors: | Babuka, David1,2 (AUTHOR) babuka@imc.cas.cz, Kolouchova, Kristyna1,3 (AUTHOR) kolouchova@imc.cas.cz, Groborz, Ondrej1,4,5 (AUTHOR) ondrej.groborz@gmail.com, Tosner, Zdenek6 (AUTHOR) zdenek.tosner@natur.cuni.cz, Zhigunov, Alexander1 (AUTHOR) zhigunov@imc.cas.cz, Stepanek, Petr1 (AUTHOR) stepanek@imc.cas.cz, Hruby, Martin1 (AUTHOR) mhruby@centrum.cz |
| Source: | Nanomaterials (2079-4991). Nov2020, Vol. 10 Issue 11, p2231-2231. 1p. |
| Subjects: | Thermoresponsive polymers, Small-angle neutron scattering, Small-angle X-ray scattering, Light scattering, Body temperature |
| Abstract: | Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 20794991 |
| DOI: | 10.3390/nano10112231 |
