Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[ N -(2-hydroxypropyl)methacrylamide]- Block -Poly[ N -(2,2-difluoroethyl)acrylamide], Prominent 19 F MRI Tracer.
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| Title: | Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[ N -(2-hydroxypropyl)methacrylamide]- Block -Poly[ N -(2,2-difluoroethyl)acrylamide], Prominent 19 F MRI Tracer. |
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| Authors: | Babuka, David1,2 (AUTHOR) babuka@imc.cas.cz, Kolouchova, Kristyna1,3 (AUTHOR) kolouchova@imc.cas.cz, Groborz, Ondrej1,4,5 (AUTHOR) ondrej.groborz@gmail.com, Tosner, Zdenek6 (AUTHOR) zdenek.tosner@natur.cuni.cz, Zhigunov, Alexander1 (AUTHOR) zhigunov@imc.cas.cz, Stepanek, Petr1 (AUTHOR) stepanek@imc.cas.cz, Hruby, Martin1 (AUTHOR) mhruby@centrum.cz |
| Source: | Nanomaterials (2079-4991). Nov2020, Vol. 10 Issue 11, p2231-2231. 1p. |
| Subjects: | Thermoresponsive polymers, Small-angle neutron scattering, Small-angle X-ray scattering, Light scattering, Body temperature |
| Abstract: | Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 147205005 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[ N -(2-hydroxypropyl)methacrylamide]- Block -Poly[ N -(2,2-difluoroethyl)acrylamide], Prominent 19 F MRI Tracer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Babuka%2C+David%22">Babuka, David</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> babuka@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Kolouchova%2C+Kristyna%22">Kolouchova, Kristyna</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> kolouchova@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Groborz%2C+Ondrej%22">Groborz, Ondrej</searchLink><relatesTo>1,4,5</relatesTo> (AUTHOR)<i> ondrej.groborz@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Tosner%2C+Zdenek%22">Tosner, Zdenek</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> zdenek.tosner@natur.cuni.cz</i><br /><searchLink fieldCode="AR" term="%22Zhigunov%2C+Alexander%22">Zhigunov, Alexander</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zhigunov@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Stepanek%2C+Petr%22">Stepanek, Petr</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> stepanek@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> mhruby@centrum.cz</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Nov2020, Vol. 10 Issue 11, p2231-2231. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Thermoresponsive+polymers%22">Thermoresponsive polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Small-angle+neutron+scattering%22">Small-angle neutron scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Small-angle+X-ray+scattering%22">Small-angle X-ray scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Light+scattering%22">Light scattering</searchLink><br /><searchLink fieldCode="DE" term="%22Body+temperature%22">Body temperature</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano10112231 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 2231 Subjects: – SubjectFull: Thermoresponsive polymers Type: general – SubjectFull: Small-angle neutron scattering Type: general – SubjectFull: Small-angle X-ray scattering Type: general – SubjectFull: Light scattering Type: general – SubjectFull: Body temperature Type: general Titles: – TitleFull: Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[ N -(2-hydroxypropyl)methacrylamide]- Block -Poly[ N -(2,2-difluoroethyl)acrylamide], Prominent 19 F MRI Tracer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Babuka, David – PersonEntity: Name: NameFull: Kolouchova, Kristyna – PersonEntity: Name: NameFull: Groborz, Ondrej – PersonEntity: Name: NameFull: Tosner, Zdenek – PersonEntity: Name: NameFull: Zhigunov, Alexander – PersonEntity: Name: NameFull: Stepanek, Petr – PersonEntity: Name: NameFull: Hruby, Martin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 10 – Type: issue Value: 11 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
