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Tomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration.

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Title: Tomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration.
Authors: Top, Can Baris1 (AUTHOR) cbtop@aselsan.com.tr, Gungor, Alper1 (AUTHOR)
Source: IEEE Transactions on Medical Imaging. Dec2020, Vol. 39 Issue 12, p4164-4173. 10p.
Subjects: Magnetic particle imaging, Magnetic field measurements, Iron oxide nanoparticles, Image reconstruction, Three-dimensional imaging, Magnets, Scanning systems, Imaging phantoms
Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have a high potential for use in clinical diagnostic and therapeutic applications. In vivo distribution of SPIONs can be imaged with the Magnetic Particle Imaging (MPI) method, which uses an inhomogeneous magnetic field with a field free region (FFR). The spatial distribution of the SPIONs are obtained by scanning the FFR inside the field of view (FOV) and sensing SPION related magnetic field disturbance. MPI magnets can be configured to generate a field free point (FFP), or a field free line (FFL) to scan the FOV. FFL scanners provide more sensitivity, and are also more suitable for scanning large regions compared to FFP scanners. Interventional procedures will benefit greatly from FFL based open magnet configurations. Here, we present the first open-sided MPI system that can electronically scan the FOV with an FFL to generate tomographic MPI images. Magnetic field measurements show that FFL can be rotated electronically in the horizontal plane and translated in three dimensions to generate 3D MPI images. Using the developed scanner, we obtained 2D images of dot and cylinder phantoms with varying iron concentrations between 11 $\mu \text{g}$ /ml and 770 $\mu \text{g}$ /ml. We used a measurement based system matrix image reconstruction method that minimizes $\ell _{{1}}$ -norm and total variation in the images. Furthermore, we present 2D imaging results of two 4 mm-diameter vessel phantoms with 0% and 75% stenosis. The experiments show high quality imaging results with a resolution down to 2.5 mm for a relatively low gradient field of 0.6 T/m. [ABSTRACT FROM AUTHOR]
Copyright of IEEE Transactions on Medical Imaging is the property of IEEE and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 147401277
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PubTypeId: academicJournal
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  Data: Tomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration.
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  Data: Superparamagnetic iron oxide nanoparticles (SPIONs) have a high potential for use in clinical diagnostic and therapeutic applications. In vivo distribution of SPIONs can be imaged with the Magnetic Particle Imaging (MPI) method, which uses an inhomogeneous magnetic field with a field free region (FFR). The spatial distribution of the SPIONs are obtained by scanning the FFR inside the field of view (FOV) and sensing SPION related magnetic field disturbance. MPI magnets can be configured to generate a field free point (FFP), or a field free line (FFL) to scan the FOV. FFL scanners provide more sensitivity, and are also more suitable for scanning large regions compared to FFP scanners. Interventional procedures will benefit greatly from FFL based open magnet configurations. Here, we present the first open-sided MPI system that can electronically scan the FOV with an FFL to generate tomographic MPI images. Magnetic field measurements show that FFL can be rotated electronically in the horizontal plane and translated in three dimensions to generate 3D MPI images. Using the developed scanner, we obtained 2D images of dot and cylinder phantoms with varying iron concentrations between 11 $\mu \text{g}$ /ml and 770 $\mu \text{g}$ /ml. We used a measurement based system matrix image reconstruction method that minimizes $\ell _{{1}}$ -norm and total variation in the images. Furthermore, we present 2D imaging results of two 4 mm-diameter vessel phantoms with 0% and 75% stenosis. The experiments show high quality imaging results with a resolution down to 2.5 mm for a relatively low gradient field of 0.6 T/m. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of IEEE Transactions on Medical Imaging is the property of IEEE and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1109/TMI.2020.3014197
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      – Code: eng
        Text: English
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      – SubjectFull: Magnetic particle imaging
        Type: general
      – SubjectFull: Magnetic field measurements
        Type: general
      – SubjectFull: Iron oxide nanoparticles
        Type: general
      – SubjectFull: Image reconstruction
        Type: general
      – SubjectFull: Three-dimensional imaging
        Type: general
      – SubjectFull: Magnets
        Type: general
      – SubjectFull: Scanning systems
        Type: general
      – SubjectFull: Imaging phantoms
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      – TitleFull: Tomographic Field Free Line Magnetic Particle Imaging With an Open-Sided Scanner Configuration.
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            NameFull: Top, Can Baris
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            NameFull: Gungor, Alper
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              M: 12
              Text: Dec2020
              Type: published
              Y: 2020
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