Bibliographic Details
| Title: |
Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles. |
| Authors: |
Baghdadi, Neazar E.1,2 (AUTHOR), Burke, Benjamin P.3 (AUTHOR), Alresheedi, Tahani2,3,4 (AUTHOR), Nigam, Shubhanchi2,3 (AUTHOR), Saeed, Abdu5 (AUTHOR), Almutairi, Farooq2,6 (AUTHOR), Domarkas, Juozas2,3 (AUTHOR), Khan, Abid3,7 (AUTHOR), Archibald, Stephen J.2,3 (AUTHOR) s.j.archibald@hull.ac.uk |
| Source: |
Dalton Transactions: An International Journal of Inorganic Chemistry. 2/7/2021, Vol. 50 Issue 5, p1599-1603. 5p. |
| Subjects: |
CXCR4 receptors, Iron oxide nanoparticles, Binding site assay, Silica, Chemokine receptors |
| Abstract: |
The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
