Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection.
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| Title: | Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection. |
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| Authors: | Meijer, Ruben P. J.1,2 (AUTHOR) R.P.J.meijer@lumc.nl, van Manen, Labrinus1 (AUTHOR) L.van_Manen@lumc.nl, Hartgrink, Henk H.1 (AUTHOR) h.h.hartgrink@lumc.nl, Burggraaf, Jacobus1,2 (AUTHOR) kb@chdr.nl, Gioux, Sylvain3 (AUTHOR) sylvain.gioux@intusurg.com, Vahrmeijer, Alexander L.1 (AUTHOR) a.l.vahrmeijer@lumc.nl, Mieog, J. Sven D.1 (AUTHOR) J.S.D.Mieog@lumc.nl |
| Source: | Journal of Biomedical Optics. Jun2021, Vol. 26 Issue 6, p60501-60501. 1p. |
| Subjects: | Indocyanine green, Fluorescence, Infrared imaging, Perfusion, Medical imaging systems, Treatment effectiveness |
| Abstract: | Significance: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has proven to be a feasible application for real-time intraoperative assessment of tissue perfusion, although quantification of NIR fluorescence signals is pivotal for standardized assessment of tissue perfusion. Aim: Four patients are described with possible compromised bowel perfusion after mesenteric resection. Based on these patients we want to emphasize the difficulties in the quantification of NIR fluorescence imaging for perfusion analysis. Approach: During image-guided fluorescence assessment, 5 mg of ICG (2.5 mg / ml) was intravenously administered by the anesthesiologist. NIR fluorescence imaging was done with the open camera system of Quest Medical Imaging. Fluorescence data taken from the regions of interest (bowel at risk, transition zone of bowel at risk and adjacent normally perfused bowel, and normally perfused reference bowel) were quantitatively analyzed after surgery for fluorescence intensity-and perfusion time-related parameters. Results: Bowel perfusion, as assessed clinically by independent surgeons based on NIR fluorescence imaging, resulted in different treatment strategies, three with excellent clinical outcome, but one with a perfusion related complication. Post-surgery quantitative analysis of fluorescence dynamics showed different patterns in the affected bowel segment compared to the unaffected reference segments for the four patients. Conclusions: Similar intraoperative fluorescence results could lead to different surgical treatment strategies, which demonstrated the difficulties in interpretation of uncorrected fluorescence signals. Real-time quantification and standardization of NIR fluorescence perfusion imaging could probably aid surgeons in the nearby future. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Biomedical Optics is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 151190204 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Meijer%2C+Ruben+P%2E+J%2E%22">Meijer, Ruben P. J.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> R.P.J.meijer@lumc.nl</i><br /><searchLink fieldCode="AR" term="%22van+Manen%2C+Labrinus%22">van Manen, Labrinus</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> L.van_Manen@lumc.nl</i><br /><searchLink fieldCode="AR" term="%22Hartgrink%2C+Henk+H%2E%22">Hartgrink, Henk H.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> h.h.hartgrink@lumc.nl</i><br /><searchLink fieldCode="AR" term="%22Burggraaf%2C+Jacobus%22">Burggraaf, Jacobus</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> kb@chdr.nl</i><br /><searchLink fieldCode="AR" term="%22Gioux%2C+Sylvain%22">Gioux, Sylvain</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> sylvain.gioux@intusurg.com</i><br /><searchLink fieldCode="AR" term="%22Vahrmeijer%2C+Alexander+L%2E%22">Vahrmeijer, Alexander L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> a.l.vahrmeijer@lumc.nl</i><br /><searchLink fieldCode="AR" term="%22Mieog%2C+J%2E+Sven+D%2E%22">Mieog, J. Sven D.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> J.S.D.Mieog@lumc.nl</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomedical+Optics%22">Journal of Biomedical Optics</searchLink>. Jun2021, Vol. 26 Issue 6, p60501-60501. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Indocyanine+green%22">Indocyanine green</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescence%22">Fluorescence</searchLink><br /><searchLink fieldCode="DE" term="%22Infrared+imaging%22">Infrared imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Perfusion%22">Perfusion</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+imaging+systems%22">Medical imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Significance: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has proven to be a feasible application for real-time intraoperative assessment of tissue perfusion, although quantification of NIR fluorescence signals is pivotal for standardized assessment of tissue perfusion. Aim: Four patients are described with possible compromised bowel perfusion after mesenteric resection. Based on these patients we want to emphasize the difficulties in the quantification of NIR fluorescence imaging for perfusion analysis. Approach: During image-guided fluorescence assessment, 5 mg of ICG (2.5 mg / ml) was intravenously administered by the anesthesiologist. NIR fluorescence imaging was done with the open camera system of Quest Medical Imaging. Fluorescence data taken from the regions of interest (bowel at risk, transition zone of bowel at risk and adjacent normally perfused bowel, and normally perfused reference bowel) were quantitatively analyzed after surgery for fluorescence intensity-and perfusion time-related parameters. Results: Bowel perfusion, as assessed clinically by independent surgeons based on NIR fluorescence imaging, resulted in different treatment strategies, three with excellent clinical outcome, but one with a perfusion related complication. Post-surgery quantitative analysis of fluorescence dynamics showed different patterns in the affected bowel segment compared to the unaffected reference segments for the four patients. Conclusions: Similar intraoperative fluorescence results could lead to different surgical treatment strategies, which demonstrated the difficulties in interpretation of uncorrected fluorescence signals. Real-time quantification and standardization of NIR fluorescence perfusion imaging could probably aid surgeons in the nearby future. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Biomedical Optics is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1117/1.JBO.26.6.060501 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 60501 Subjects: – SubjectFull: Indocyanine green Type: general – SubjectFull: Fluorescence Type: general – SubjectFull: Infrared imaging Type: general – SubjectFull: Perfusion Type: general – SubjectFull: Medical imaging systems Type: general – SubjectFull: Treatment effectiveness Type: general Titles: – TitleFull: Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Meijer, Ruben P. J. – PersonEntity: Name: NameFull: van Manen, Labrinus – PersonEntity: Name: NameFull: Hartgrink, Henk H. – PersonEntity: Name: NameFull: Burggraaf, Jacobus – PersonEntity: Name: NameFull: Gioux, Sylvain – PersonEntity: Name: NameFull: Vahrmeijer, Alexander L. – PersonEntity: Name: NameFull: Mieog, J. Sven D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 10833668 Numbering: – Type: volume Value: 26 – Type: issue Value: 6 Titles: – TitleFull: Journal of Biomedical Optics Type: main |
| ResultId | 1 |
