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On the role of vesicle transport in neurite growth: Modeling and experiments.

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Title: On the role of vesicle transport in neurite growth: Modeling and experiments.
Authors: Humpert, Ina1 (AUTHOR) ina.humpert@uni-muenster.de, Di Meo, Danila2 (AUTHOR) d_dime01@uni-muenster.de, Püschel, Andreas W.2 (AUTHOR) apuschel@uni-muenster.de, Pietschmann, Jan-Frederik3 (AUTHOR) jfpietschmann@math.tu-chemnitz.de
Source: Mathematical Biosciences. Aug2021, Vol. 338, pN.PAG-N.PAG. 1p.
Subjects: Phenomenological biology, Neuron development, Transport theory, Models & modelmaking, Neurons
Abstract: The processes that determine the establishment of the complex morphology of neurons during development are still poorly understood. Here, we focus on the question how a difference in the length of neurites affects vesicle transport. We performed live imaging experiments and present a lattice-based model to gain a deeper theoretical understanding of intracellular transport in neurons. After a motivation and appropriate scaling of the model we present numerical simulations showing that initial differences in neurite length result in phenomena of biological relevance, i.e. a positive feedback that enhances transport into the longer neurite and oscillation of vesicles concentrations that can be interpreted as cycles of extension and retraction observed in experiments. Thus, our model is a first step towards a better understanding of the interplay between the transport of vesicles and the spatial organization of cells. • Discrete model for vesicle transport with two species and size exclusion. • Experiments and theory suggest that transport increases in neurites with length advantage. • Length differences result in oscillations of vesicle concentration as observed in experiments. • Vesicle transport is linked to changes in neurite length. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
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Abstract:The processes that determine the establishment of the complex morphology of neurons during development are still poorly understood. Here, we focus on the question how a difference in the length of neurites affects vesicle transport. We performed live imaging experiments and present a lattice-based model to gain a deeper theoretical understanding of intracellular transport in neurons. After a motivation and appropriate scaling of the model we present numerical simulations showing that initial differences in neurite length result in phenomena of biological relevance, i.e. a positive feedback that enhances transport into the longer neurite and oscillation of vesicles concentrations that can be interpreted as cycles of extension and retraction observed in experiments. Thus, our model is a first step towards a better understanding of the interplay between the transport of vesicles and the spatial organization of cells. • Discrete model for vesicle transport with two species and size exclusion. • Experiments and theory suggest that transport increases in neurites with length advantage. • Length differences result in oscillations of vesicle concentration as observed in experiments. • Vesicle transport is linked to changes in neurite length. [ABSTRACT FROM AUTHOR]
ISSN:00255564
DOI:10.1016/j.mbs.2021.108632